Academic Unit of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.
Expert Rev Gastroenterol Hepatol. 2020 Mar;14(3):147-154. doi: 10.1080/17474124.2020.1725472. Epub 2020 Feb 13.
: This article provides a comprehensive overview of the development and application of serological tests used routinely in clinical practice for the diagnosis and management of adult celiac disease.: We summarize existing scientific literature related to anti-endomyseal, anti-tissue transglutaminase, and anti-deamidated gliadin peptide antibodies and detail the current and potential future applications of these tests in celiac disease.: Current serological tests in celiac disease have some of the best performance characteristics among disease-specific tests. However, in adult celiac disease, current diagnostic algorithms still rely on duodenal biopsies to confirm the diagnosis. A 'biopsy avoidance strategy' has been implemented in pediatric celiac disease. Future high-quality studies will help inform on whether this approach can be implemented into adult gastroenterology services. It is envisaged that the next 5 years will see an increasing reliance on serology in the diagnosis of adult celiac disease.
本文全面概述了在临床实践中用于诊断和管理成人乳糜泻的常规血清学检测的发展和应用。我们总结了与抗内膜、抗组织转谷氨酰胺酶和抗脱酰胺麦胶蛋白肽抗体相关的现有科学文献，并详细介绍了这些检测在乳糜泻中的当前和潜在未来应用。目前乳糜泻的血清学检测在疾病特异性检测中具有最佳的性能特征之一。然而，在成人乳糜泻中，目前的诊断算法仍依赖于十二指肠活检来确认诊断。在小儿乳糜泻中已经实施了“避免活检策略”。未来的高质量研究将有助于了解这种方法是否可以应用于成人胃肠病学服务。预计未来 5 年内，血清学检测在成人乳糜泻的诊断中将越来越重要。
