Royal Hallamshire Hospital, Sheffield, UK;
Royal Hallamshire Hospital, Sheffield, UK.
Clin Med (Lond). 2021 Mar;21(2):127-130. doi: 10.7861/clinmed.2021-0025.
Coeliac disease (CD) is a common autoimmune-mediated gluten sensitive enteropathy, with a prevalence of around 1%. While the incidence of CD has increased over the last 2 decades, many cases still remain undiagnosed. The presentation of CD is variable and can be subtle, with it being important to explore both gastrointestinal and extra-intestinal features. The cornerstone of management is adherence to a strict gluten free diet, which requires support and education from an expert gastrointestinal dietitian. Persisting symptoms in individuals requires re-evaluation, with repeat duodenal biopsies sometimes required. Refractory CD affects a small subset of individuals with CD, requiring specialist input.
乳糜泻（CD）是一种常见的自身免疫性麸质敏感肠病，患病率约为 1%。尽管 CD 的发病率在过去 20 年中有所增加，但仍有许多病例未被诊断。CD 的表现多种多样，可能较为隐匿，因此重要的是要探索胃肠道和非胃肠道的特征。其治疗的基石是坚持严格的无麸质饮食，这需要来自专家级胃肠病营养师的支持和教育。对于持续存在症状的患者需要重新评估，有时需要重复十二指肠活检。难治性 CD 影响一小部分 CD 患者，需要专家的介入。
