Washington N, Wilson C G, Greaves J L, Danneskiold-Samsøe P
Dept. of Physiology, Queen's Medical Centre, Nottingham, U.K.
Scand J Gastroenterol. 1988 Oct;23(8):920-4. doi: 10.3109/00365528809090147.
The gastric distribution and residence time of a new pectin-containing formulation, FF5005 (Farma Food A/S, Denmark), was investigated by using the technique of gamma scintigraphy in six healthy volunteers after administration with a radiolabelled meal. The formulation and test meal were radiolabelled with indium-113m and technetium-99m, respectively, and the formulation was administered to the subjects 30 min after the labelled meal. FF5005 was shown to float and form a discrete phase on top of the stomach contents and emptied from the stomach more slowly than the food (p less than 0.05, Wilcoxon signed rank test). The times taken for the formulation and test meal to half-empty from the stomach (T50) were 4.13 +/- 0.69 h (mean +/- SD) and 2.17 +/- 0.15 h (mean +/- SD), respectively. Greater than 50% of the formulation remained in the fundal region of the stomach for 3 h. FF5005 produced in vivo behaviour similar to that of established alginate-containing anti-reflux agents, and the pectin content of the formulation was shown to decrease the rate of emptying of the meal.
采用γ闪烁扫描技术，在6名健康志愿者摄入放射性标记餐食之后，对一种新型含果胶制剂FF5005（丹麦法马食品公司）在胃部的分布情况和停留时间进行了研究。该制剂和测试餐食分别用铟-113m和锝-99m进行放射性标记，在标记餐食30分钟后给受试者服用该制剂。结果显示，FF5005会漂浮在胃内容物上方并形成一个离散相，从胃中排空的速度比食物慢（Wilcoxon符号秩检验，p<0.05）。该制剂和测试餐食从胃中排空一半所需的时间（T50）分别为4.13±0.69小时（均值±标准差）和2.17±0.15小时（均值±标准差）。超过50%的制剂在胃底部区域停留了3小时。FF5005在体内的行为与已有的含海藻酸盐抗反流制剂相似，且该制剂中的果胶成分被证明会降低餐食的排空速度。
