Malmqvist K G, Brun A, Inamura K, Martins E, Salford L G, Siesjö B K, Tapper U A, Themner K
Dept. Nuclear Physics, Lund Inst. Sci. & Technol., Sweden.
Scanning Microsc. 1988 Sep;2(3):1685-93.
Particle Induced X-ray Emission and proton microprobe analyses have been applied for the investigation of regional elemental distributions in connection with various pathological states in the brain. Malignant brain tumours and adjacent histologically intact tissue removed during surgery were analysed with PIXE. Systematic elemental variations, e.g., for calcium and selenium, were observed in the tumour front. The proton microprobe was applied to study the Ca and K concentrations in various cell strata in hippocampus following transient ischaemia in rat brain. Significant increases in the Ca level occurred in selectively vulnerable cells within 48 h after the ischaemia.
粒子诱导X射线发射和质子微探针分析已被用于研究与大脑各种病理状态相关的区域元素分布。对手术切除的恶性脑肿瘤及相邻组织学上完整的组织进行了PIXE分析。在肿瘤前沿观察到了系统性的元素变化，例如钙和硒的变化。应用质子微探针研究了大鼠脑短暂缺血后海马体不同细胞层中的钙和钾浓度。缺血后48小时内，选择性易损细胞中的钙水平显著升高。
