溶酶体异常与心血管疾病
Lysosomal Abnormalities in Cardiovascular Disease.
机构信息
Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
出版信息
Int J Mol Sci. 2020 Jan 27;21(3):811. doi: 10.3390/ijms21030811.
Abstract
The lysosome, a key organelle for cellular clearance, is associated with a wide variety of pathological conditions in humans. Lysosome function and its related pathways are particularly important for maintaining the health of the cardiovascular system. In this review, we highlighted studies that have improved our understanding of the connection between lysosome function and cardiovascular diseases with an emphasis on a recent breakthrough that characterized a unique autophagosome-lysosome fusion mechanism employed by cardiomyocytes through a lysosomal membrane protein LAMP-2B. This finding may impact the development of future therapeutic applications.
摘要
溶酶体是细胞清除的关键细胞器，与人类的多种病理状况有关。溶酶体的功能及其相关途径对于维持心血管系统的健康尤为重要。在这篇综述中，我们强调了一些研究，这些研究增进了我们对溶酶体功能与心血管疾病之间联系的理解，重点介绍了最近的一项突破，该突破通过溶酶体膜蛋白 LAMP-2B 描述了心肌细胞所采用的独特的自噬体-溶酶体融合机制。这一发现可能会影响未来治疗应用的发展。
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