CirTech Institute, HCMC University of Technology (HUTECH), Ho Chi Minh City 700000, Vietnam.
Institute of Applied Science, HCMC University of Technology (HUTECH), Ho Chi Minh City 700000, Vietnam.
Biomolecules. 2020 Jan 29;10(2):201. doi: 10.3390/biom10020201.
Bonati. () has been used in traditional and modern medicine in Vietnam for curing hepatitis. In this study, ethanol and aqueous extracts of were evaluated for their α-glucosidase inhibitory activities and anti-hyperglycemic effects on glucose loaded hyperglycemic and streptozotocin (STZ) induced diabetic mice. The α-glucosidase inhibition of the extracts was evaluated by colorimetric assays, and the anti-diabetic activity was tested on a STZ-induced diabetic mice model. The ethanol and aqueous extracts showed a significant α-glucosidase inhibitory activity, which was more effective than acarbose at the same concentration. In the STZ-induced diabetic mice, both extracts showed a strong anti-hyperglycemic activity, with the group receiving 50 mg/kg of ethanol extract and the group receiving 50 mg/kg of aqueous extract presenting 64.42% and 57.69% reductions, respectively, in the blood glucose levels when compared with the diabetic control group, on day 21 (). Isoscutellarein-8-O-β-D-glucopyranoside (IG) was identified from the ethanol extract, which showed a strong inhibitory activity against α-glucosidase, with a ten times higher potency compared with the positive control acarbose. The anti-hyperglycemic effect of IG was effectively similar to the standard drug, glibenclamide, at the same dose of 10 mg/kg (). These results indicated that has a great antidiabetic potential.
Bonati. () 在越南传统医学和现代医学中被用于治疗肝炎。在这项研究中，评估了 的乙醇和水提取物对α-葡萄糖苷酶的抑制活性以及对葡萄糖负荷性高血糖和链脲佐菌素 (STZ) 诱导的糖尿病小鼠的抗高血糖作用。通过比色法评估提取物的α-葡萄糖苷酶抑制作用，并在 STZ 诱导的糖尿病小鼠模型上测试抗糖尿病活性。乙醇和水提取物显示出显著的α-葡萄糖苷酶抑制活性，其在相同浓度下比阿卡波糖更有效。在 STZ 诱导的糖尿病小鼠中，两种提取物均表现出很强的抗高血糖活性，接受 50mg/kg 乙醇提取物的组和接受 50mg/kg 水提取物的组的血糖水平分别降低了 64.42%和 57.69%，与糖尿病对照组相比，在第 21 天 ()。从乙醇提取物中鉴定出了山柰素-8-O-β-D-吡喃葡萄糖苷 (IG)，其对α-葡萄糖苷酶表现出强烈的抑制活性，其效力比阳性对照阿卡波糖高 10 倍。IG 的抗高血糖作用与标准药物格列本脲在相同剂量 10mg/kg 时的作用有效相似 ()。这些结果表明，Bonati. 具有很大的抗糖尿病潜力。
