Department of Biology, Can Tho University, Can Tho City, Vietnam.
Phan Van Tri High School, Can Tho University, Can Tho City, Vietnam.
Indian J Pharmacol. 2023 Jul-Aug;55(4):237-242. doi: 10.4103/ijp.ijp_253_23.
Balanophora latisepala (BL) is a chlorophyll-free and obligate parasitic plant found across mountainous areas of An Giang, Vietnam. This study was conducted to evaluate the effectiveness of extracts from BL, herbs mentioned in many traditional medicines in the treatment of diabetes, on laboratory mice.
The effects of BL aqueous, methanol, and ethanol extracts on the blood glucose levels, hematological indices, liver enzymes, and pancreatic tissue structure of normal, glucose-tolerant mice, and diabetic mice treated with streptozotocin (STZ) were assessed. Mice were orally administered extracts at a concentration of 500 mg/kg.
The aqueous and ethanol extracts did not affect the blood glucose levels of healthy and glucose-tolerant mice (P > 0.05). The methanol extract reduced the blood glucose of healthy mice (P < 0.05) but did not affect the blood glucose of glucose-tolerant mice 3 h after administration (P > 0.05). When taking the methanol and ethanol extracts, the diabetic mice experienced a 45.67% and a 40.33% decrease in blood glucose levels after 21 days of research, respectively. Aqueous extract and gliclazide (10 mg/kg) showed no effect on reducing blood glucose levels in diabetic mice over the 21 days of the study. Both methanol and ethanol extracts were effective in regulating liver enzyme levels in diabetic mice. In both untreated and treated diabetic mice, pancreatic islet structures were degraded with the appearance of gaps resulting from β-cell degeneration.
This implies that ethanol extracts have potential applications in regulating blood glucose levels.
巴兰诺菲亚latisepala（BL）是一种叶绿素缺乏且专性寄生植物，分布于越南安江省的山区。本研究旨在评估 BL 水提物、甲醇提物和乙醇提物对实验室小鼠血糖水平、血液学指标、肝酶和胰腺组织结构的影响，这些提取物均来自许多传统药物中提到的草药。
我们评估了 BL 水提物、甲醇提物和乙醇提物对正常、糖耐量正常小鼠和链脲佐菌素（STZ）处理的糖尿病小鼠血糖水平、血液学指标、肝酶和胰腺组织结构的影响。小鼠以 500mg/kg 的浓度口服给予提取物。
水提物和乙醇提物对健康和糖耐量正常小鼠的血糖水平没有影响（P＞0.05）。甲醇提物降低了健康小鼠的血糖（P＜0.05），但给药 3 小时后对糖耐量正常小鼠的血糖没有影响（P＞0.05）。在服用甲醇和乙醇提取物时，糖尿病小鼠在 21 天的研究中血糖水平分别下降了 45.67%和 40.33%。水提物和格列齐特（10mg/kg）在 21 天的研究中均未显示出降低糖尿病小鼠血糖水平的作用。甲醇和乙醇提取物均能有效调节糖尿病小鼠的肝酶水平。在未经治疗和治疗的糖尿病小鼠中，胰岛结构退化，β细胞变性导致出现间隙。
这表明乙醇提取物具有调节血糖水平的潜力。
