Uyar A, Abdulrahman N T
Department of Pathology, Veterinary Faculty, Mustafa Kemal University, Hatay, Turkey.
Department of Pathology, Veterinary Faculty, Yuzuncu Yil University, Van, Turkey.
Biotech Histochem. 2020 Feb;95(2):92-104. doi: 10.1080/10520295.2019.1612092. Epub 2020 Feb 4.
We investigated the antidiabetic activity of (PT) extracts in streptozotocin (STZ) induced diabetic rats. We used 40 Wistar albino male rats divided into five groups: control (C), diabetes (DM), diabetes + acarbose (DM + AC), diabetes + PT (DM + PT) and PT. DM was established by intraperitoneal injection of STZ. Immunohistochemistry revealed that STZ reduced insulin immunoreactivity in the pancreas of the diabetic rats. To the contrary, insulin immunoreactivity in the pancreatic β cells of PT treated diabetic rats was increased significantly. Decreased levels of blood glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glucose, total triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) were found in the PT supplemented diabetic group. Also, malondialdehyde (MDA) and antioxidant defense system enzyme levels were normalized in the DM + PT group. PT exhibited a protective effect on liver, kidney and pancreas that had been damaged by STZ induced DM.
我们研究了[提取物名称未给出]（PT）提取物对链脲佐菌素（STZ）诱导的糖尿病大鼠的抗糖尿病活性。我们使用了40只雄性Wistar白化大鼠，分为五组：对照组（C）、糖尿病组（DM）、糖尿病+阿卡波糖组（DM+AC）、糖尿病+PT组（DM+PT）和PT组。通过腹腔注射STZ诱导糖尿病模型。免疫组织化学显示，STZ降低了糖尿病大鼠胰腺中的胰岛素免疫反应性。相反，PT治疗的糖尿病大鼠胰腺β细胞中的胰岛素免疫反应性显著增加。在补充PT的糖尿病组中，血糖、天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、碱性磷酸酶（ALP）、乳酸脱氢酶（LDH）、葡萄糖、总甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）水平降低。此外，DM+PT组中的丙二醛（MDA）和抗氧化防御系统酶水平恢复正常。PT对因STZ诱导的糖尿病而受损的肝脏、肾脏和胰腺具有保护作用。
