早期阿尔茨海默病中神经精神因素对决策的影响。
Neuropsychiatric Effects on Decision-Making in Early Alzheimer Disease.
作者信息
Yerstein Oleg, Carr Andrew R, Jimenez Elvira, Mendez Mario F
机构信息
VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
出版信息
J Geriatr Psychiatry Neurol. 2020 Mar;33(2):68-72. doi: 10.1177/0891988719888292.
BACKGROUND
Neuropsychiatric symptoms can impact decision-making in patients with Alzheimer disease (AD).
METHODS
Using a simple decision-making task, a variant of the ultimatum game (UG) modified to control feelings of unfairness, this study investigated rejection responses among responders to unfair offers. The UG was administered to 11 patients with AD, 10 comparably demented patients with behavioral variant frontotemporal dementia (bvFTD), and 9 healthy controls (HC). The results were further compared with differences on the caregiver Neuropsychiatric Inventory (NPI).
RESULTS
Overall, patients with AD significantly rejected more total offers than did the patients with bvFTD and the HC ( < .01). On the NPI, the only domain that was significantly worse among the patients with AD compared to the other groups was dysphoria/depression.
CONCLUSIONS
These results suggest that early AD can be distinguished based on increased rejections of offers in decision-making, possibly consequent to a heightened sense of unfairness from dysphoria/depression.
背景
神经精神症状会影响阿尔茨海默病（AD）患者的决策。
方法
本研究采用一种简单的决策任务，即对最后通牒博弈（UG）进行变体修改以控制不公平感，调查了回应者对不公平提议的拒绝反应。该UG测试应用于11例AD患者、10例患有行为变异型额颞叶痴呆（bvFTD）的痴呆程度相当的患者以及9名健康对照者（HC）。结果进一步与照顾者神经精神科问卷（NPI）的差异进行比较。
结果
总体而言，AD患者拒绝的提议总数显著多于bvFTD患者和HC（<0.01）。在NPI上，与其他组相比，AD患者中唯一显著更差的领域是烦躁/抑郁。
结论
这些结果表明，早期AD可根据决策中对提议拒绝的增加来区分，这可能是由于烦躁/抑郁导致的不公平感增强所致。
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