Research Center for Sport and Physical Activity, CIDAF (UID/PTD/04213/2019), Faculty of Sports Sciences and Physical Education (FCDEF-UC) - University of Coimbra, Coimbra, Portugal.
Reserch Unit in Sport and Health, Department of Physical Education and Sports, University of Valencia, Valencia, Spain.
Curr Pharm Des. 2020;26(9):906-915. doi: 10.2174/1381612826666200203123258.
Frail individuals experience an accelerated immunosenescence, and exercise has been identified as a therapy to promote a better inflammatory environment.
To analyze the effects of 28-weeks of two different exercise protocols on the functional fitness and immune profiles of institutionalized pre-frail and frail women with mild cognitive impairment.
Participants residing in care homes (n=60, 81±7.84 years old) were randomized into three groups: a chair elastic band muscle-strength exercise (CSE, n=21; 81±4.79), a chair multimodal exercise (CME, n=20; 80±8.19), and a control non-exercise (CGne, n=19; 80±10.01). Both CME and CSE groups performed progressive circuit-training exercise sessions. The controls did not change their usual lifestyle. The Fried protocol and the Mini-Mental State Examination questionnaire were used to identify the frail subgroups and the participants with mild cognitive impairment. Data for anti and pro-inflammatory markers and physical fitness were analyzed pre and post-interventions.
After the intervention, a significant effect of time and time by group for sIgA and time by group for IL- 10 levels were found (p > 0.05). Within-group analysis showed a significant moderate decrease in the TNF-α to IL-10 ratio for the CME group and an increase in the controls (p > 0.05) and a slight reduction in the IL-6 and IL- 1β concentrations. The controls showed a negative trend towards a decrease in physical fitness and a trend for increased levels in the pro-inflammatory markers IL-6 and IL-1β.
The evidence regarding the use of systematic and moderate long-term exercise as therapy for promoting a better balance between pro- and anti-inflammatory environments and a decrease in the inflammatory index for the CME group were the most promising results from this study.
虚弱个体经历加速的免疫衰老，运动已被确定为促进更好炎症环境的一种疗法。
分析 28 周两种不同运动方案对机构化衰弱前期和衰弱期伴有轻度认知障碍的女性的功能性体能和免疫特征的影响。
居住在养老院的参与者（n=60，81±7.84 岁）被随机分为三组：椅子弹性带肌肉力量锻炼（CSE，n=21；81±4.79）、椅子多模式锻炼（CME，n=20；80±8.19）和对照组非运动（CGne，n=19；80±10.01）。CME 和 CSE 组均进行渐进式循环训练运动。对照组不改变其日常的生活方式。采用 Fried 方案和简易精神状态检查问卷识别衰弱亚组和伴有轻度认知障碍的参与者。分析干预前后的抗炎和促炎标志物及身体适应性数据。
干预后，发现 sIgA 存在时间和时间与组间的显著效应，以及 IL-10 水平存在时间与组间的显著效应（p > 0.05）。组内分析显示，CME 组 TNF-α 与 IL-10 比值有显著的中度下降，对照组有增加（p > 0.05），IL-6 和 IL-1β 浓度略有下降。对照组的身体适应性呈现出下降的负趋势，促炎标志物 IL-6 和 IL-1β 水平也呈上升趋势。
本研究中，最有希望的结果是，系统和适度的长期运动作为改善促炎和抗炎环境之间平衡以及降低 CME 组炎症指数的疗法的证据。
