Giannopoulos Anthony J, Kottaras Steve, Allanigue Bryan, Coish Jeremia M, Ditor David S, Fajardo Val A, Klentrou Panagiota
Department of Kinesiology, Brock University, St. Catharines, ON L2S 3A1, Canada.
Core Health Collective, St. Catharines, ON L2R 5J3, Canada.
Nutrients. 2025 Apr 4;17(7):1265. doi: 10.3390/nu17071265.
: This study piloted a 24-week bodybuilding program combining resistance training (RT) with a dietary bulk-and-cut protocol in middle-aged adult males. : Seven untrained males (33 ± 3.0 years; BMI = 35.0 ± 4.6 kg/m; body fat = 36 ± 5%) completed a 24-week intervention combining RT with a dietary protocol consisting of 12-week cycles of caloric bulking (0-12 weeks) and cutting (12-24 weeks). The participant retention rate was 64%, while compliance with training was 96.7%, and adherence to dietary cycles was over 93%. To assess the preliminary efficacy of the intervention, venous blood samples and measurements of body composition (BodPod), muscle strength, and VOmax (cycle ergometer) were collected at baseline (week 0) and following the bulking (week 12) and cutting (week 24) cycles. Circulating lipids (triglycerides, total, low-density, and high-density cholesterol), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) were measured in serum. : The training led to significant increases in muscle strength, especially in the deadlift (+46%, < 0.001) and squat (+65%, < 0.001). Improvements in body composition were characterized by an increase in fat-free mass and a decrease in body fat percentage over the 24-week intervention (+3% and -6%, respectively, < 0.05). Lipids, CRP, IL-6, and IL-10 did not change significantly, but there was a notable reduction in TNF-α (time effect = 0.05, η = 0.39), with 15% lower concentrations at week 24 compared to baseline, indicating reduced inflammation. : Overall, the pilot intervention achieved high compliance and adherence rates, leading to improvements in body composition and lower resting TNF-α concentrations in a group of middle-aged males with obesity.
本研究在中年成年男性中试行一项为期24周的健身计划，该计划将阻力训练（RT）与饮食增肌减脂方案相结合。7名未经训练的男性（33±3.0岁；体重指数=35.0±4.6kg/m；体脂率=36±5%）完成了一项为期24周的干预，该干预将阻力训练与饮食方案相结合，饮食方案包括12周的热量增加期（0至12周）和减脂期（12至24周）。参与者保留率为64%，训练依从性为96.7%，饮食周期依从性超过93%。为评估该干预的初步效果，在基线期（第0周）、增肌期（第12周）和减脂期（第24周）结束后采集静脉血样本，并测量身体成分（体脂仪）、肌肉力量和最大摄氧量（功率自行车）。检测血清中的循环脂质（甘油三酯、总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和白细胞介素-10（IL-10）。训练导致肌肉力量显著增加，尤其是硬拉（增加46%，P<0.001）和深蹲（增加65%，P<0.001）。在24周的干预中，身体成分的改善表现为去脂体重增加和体脂百分比降低（分别增加3%和降低6%，P<0.05）。脂质、CRP、IL-6和IL-10没有显著变化，但TNF-α有显著降低（时间效应P=0.05，η=0.39），与基线相比，第24周时浓度降低了15%，表明炎症减轻。总体而言，该初步干预取得了较高的依从性和坚持率，使一组肥胖中年男性的身体成分得到改善，静息TNF-α浓度降低。
