Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Clinical Immunology Research Center, Ali-ebne Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.
Curr Drug Discov Technol. 2021;18(2):225-234. doi: 10.2174/1570163817666200203110803.
Cancer is one of the most prevalent diseases associated with heavy complications in treatment. Mucotoxic cancer therapies such as head and neck radiotherapy and some of the chemotherapy agents may lead to oral mucositis. In addition to its economic consequences, mucositis also affects patients' quality of life. In Traditional Persian Medicine (TPM) manuscripts, several medicaments have been suggested for the treatment of mucositis.
Considering the public welcome for herbal medicine, the current evidence-based review study is conducted to investigate the herbal remedies which have been proposed for oral mucositis in TPM.
At first, a comprehensive survey was done on Qanon fi al-Teb, which is the most important textbook of TPM; then the scientific name of the herbs was authenticated according to the botanical textbooks. At last, data banks including Scopus, Pubmed, Web of science and Science direct were investigated for possible relevant properties of each medicinal plant in the literature.
In total, 30 herbs are introduced in this study. According to the registered documents, 18 herbs are reported to have antioxidant, anti-inflammatory, antimicrobial, anti-nociceptive and wound healing properties of which the therapeutic effect of only a few herbs including Glycyrrhiza glabra, Malva sylvestris, Morus nigra, Punica granatum, and Solanum nigrum were directly evaluated against oral mucositis on the literature.
Despite the lack of human studies on mucositis for the other discussed herbs, their related pharmacological properties can be considered for new natural drug discovery supported by medieval and traditional experiments.
癌症是最常见的疾病之一，其治疗过程中并发症较为严重。头颈部放疗和一些化疗药物等黏膜毒性癌症治疗方法可导致口腔黏膜炎。除了会带来经济后果，口腔黏膜炎还会影响患者的生活质量。在传统波斯医学（TPM）文献中，有几种药物被建议用于治疗口腔黏膜炎。
鉴于草药深受公众欢迎，本项基于循证的综述研究旨在调查 TPM 中提出的用于口腔黏膜炎的草药疗法。
首先，对 TPM 最重要的教科书《Qanon fi al-Teb》进行了全面调查；然后根据植物学教科书对草药的学名进行了验证。最后，调查了 Scopus、Pubmed、Web of science 和 Science direct 等数据库，以在文献中查找每种药用植物的可能相关特性。
本研究共介绍了 30 种草药。根据登记文件，有 18 种草药具有抗氧化、抗炎、抗菌、抗伤害和伤口愈合的特性，其中仅有少数几种草药（如甘草、野锦葵、黑桑、石榴和龙葵）的治疗效果在文献中直接针对口腔黏膜炎进行了评估。
尽管其他讨论的草药在口腔黏膜炎方面缺乏人体研究，但可以考虑根据中世纪和传统实验，为新的天然药物发现提供其相关的药理学特性。
