Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Curr Drug Discov Technol. 2021;18(2):160-178. doi: 10.2174/1570163817666200517115438.
Vitiligo is a hypopigmentation disorder that affects 1% of the world's population. Vitiligo causes white spots on the skin, mucous membranes, or white hair by destroying skin melanocytes. The pathogenesis of vitiligo is unknown but autoimmune, autocytotoxic, and neural mechanisms are suggested. According to the autoimmune theory, in people with vitiligo, immune cells invade and damage melanocytes. T cells are more commonly present in vitiligo patients' skin and remain in the lesion site, which is composed of CD8 and CD4 T cells. Many studies have been conducted on the presence and role of cytokines such as interleukins and interferongamma (IFN-γ) in the vitiligo process.
This study aimed to introduce herbs effective against vitiligo from the perspective of Persian medicine and to investigate their possible therapeutic mechanisms with the possible effects of herbs on autoimmune mechanisms.
For this purpose, keywords were used to extract data from Persian medicine textbooks, and then relevant scientific databases, including Google Scholar, PubMed, Web of Science, and Scopus were examined.
It was found that Persian medicine scholars used 50 different medicinal plants to treat and reduce the complications of vitiligo, and recent scientific studies have proven immune-regulating properties and reducing the effect of many of them on cytokines.
According to scientific evidence on immunomodulatory effects, new research into the effects of these plants on vitiligo can lead to the discovery of new drugs and approaches for treating this disease.
白癜风是一种色素减退性疾病，影响全球 1%的人口。白癜风通过破坏皮肤黑素细胞导致皮肤、黏膜或白发出现白色斑点。白癜风的发病机制尚不清楚，但自身免疫、自体细胞毒性和神经机制被提出。根据自身免疫理论，在白癜风患者中，免疫细胞侵袭并损伤黑素细胞。T 细胞在白癜风患者的皮肤中更为常见，并存在于病变部位，由 CD8 和 CD4 T 细胞组成。许多研究已经对白细胞介素和干扰素γ（IFN-γ）等细胞因子在白癜风过程中的存在和作用进行了研究。
本研究旨在从波斯医学的角度介绍治疗白癜风的草药，并探讨其可能的治疗机制，以及草药对自身免疫机制的可能影响。
为此，使用关键词从波斯医学教科书提取数据，然后检查包括 Google Scholar、PubMed、Web of Science 和 Scopus 在内的相关科学数据库。
发现波斯医学学者使用了 50 种不同的药用植物来治疗和减轻白癜风的并发症，最近的科学研究已经证明了它们中的许多对免疫调节和减少细胞因子的作用。
根据免疫调节作用的科学证据，对这些植物治疗白癜风的作用进行新的研究可能会发现治疗这种疾病的新药和方法。
