Biomaterials and Tissue Engineering Department, School of Advanced Technology in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
Int J Biol Macromol. 2020 Apr 15;149:783-793. doi: 10.1016/j.ijbiomac.2020.01.300. Epub 2020 Jan 31.
One of the most popular types of bone cements is polymethylmethacrylate (PMMA). The properties of this bone cement have attracted many researchers effort to modify its properties. In this study, after preparation of chitosan (Cs) powder and Cs/graphene oxide (GO) nanocomposite powder, they were added homogeneously to the PMMA bone cement with different percentages. The results showed that the addition of 25 wt% of Cs/GO nanocomposite powder to the PMMA bone cement cause to increase the compressive strength by 16.2%, the compressive modulus by 69.1% and the bending strength by 24.0%. The obtained results showed that by adding Cs/GO nanocomposite powder to the PMMA bone cement, setting time and injectability were increased, maximum temperature was decreased and apatite-like deposition was increased after 4 weeks of incubation in SBF solution. The results of MG-63 cell culture confirmed the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement. Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
最常见的骨水泥类型之一是聚甲基丙烯酸甲酯（PMMA）。这种骨水泥的特性吸引了许多研究人员努力改进其性能。在这项研究中，在制备壳聚糖（Cs）粉末和 Cs/氧化石墨烯（GO）纳米复合材料粉末后，将它们以不同的百分比均匀添加到 PMMA 骨水泥中。结果表明，将 25wt%的 Cs/GO 纳米复合材料粉末添加到 PMMA 骨水泥中会使抗压强度提高 16.2%，压缩模量提高 69.1%，弯曲强度提高 24.0%。所得结果表明，通过向 PMMA 骨水泥中添加 Cs/GO 纳米复合材料粉末，可提高凝固时间和可注射性，降低最大温度，并在 SBF 溶液孵育 4 周后增加类磷灰石沉积。MG-63 细胞培养的结果证实了 25wt%PMMA-Cs/GO 复合骨水泥对细胞活力、生长和细胞黏附的提高。因此，可以得出结论，具有改善的机械、物理和生物性能的 25wt%PMMA-Cs/GO 复合骨水泥可以成为骨科应用中普通商用骨水泥的良好替代品。
