Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL, USA.
Section of Neonatal-Perinatal Medicine, University of Oklahoma College of Medicine, Oklahoma City, OK, USA.
Nitric Oxide. 2020 Apr 1;97:27-32. doi: 10.1016/j.niox.2020.01.012. Epub 2020 Jan 31.
Hydrogen sulfide, nitric oxide, and carbon monoxide are endogenously produced gases that regulate various signaling pathways. The role of these transmitters is complex as constitutive production of these molecules may have anti-inflammatory, anti-microbial, and/or vasodilatory effects whereas induced production or formation of secondary metabolites may lead to cellular death. Given this fine line between friend and foe, therapeutic attenuation of these molecules' production has involved both inhibition of endogenous formation and therapeutic supplementation. All three gases have been implicated as regulators of critical aspects of neonatal physiology, and in turn, comorbidities including necrotizing enterocolitis, hypoxic ischemic encephalopathy, and pulmonary hypertension. In this review, we present current perspectives on these associations, highlight areas where insights remain sparse, and identify areas for potential for future investigations.
硫化氢、一氧化氮和一氧化碳是内源性气体，可调节各种信号通路。这些递质的作用很复杂，因为这些分子的组成型产生可能具有抗炎、抗微生物和/或血管扩张作用，而诱导性产生或次生代谢物的形成可能导致细胞死亡。鉴于这种敌我之间的微妙关系，这些分子产生的治疗性抑制作用既包括内源性形成的抑制，也包括治疗性补充。这三种气体都被认为是新生儿生理学关键方面的调节剂，反过来又与包括坏死性小肠结肠炎、缺氧缺血性脑病和肺动脉高压在内的合并症有关。在这篇综述中，我们介绍了这些关联的最新观点，强调了见解仍然匮乏的领域，并确定了未来研究的潜力领域。
