Centre for Behavioural Sciences and Mental Health, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy.
Department of Molecular Medicine, Sapienza University, Viale Regina Elena, 291-293, 00161 Rome, Italy.
Neurosci Biobehav Rev. 2020 May;112:254-269. doi: 10.1016/j.neubiorev.2020.01.038. Epub 2020 Jan 31.
In the last two decades, there has been increasing research interest in disentangling the contribution of genetic and environmental factors to individual differences in attachment, and in identifying the genes involved in shaping attachment. Twin studies suggest that as attachment changes during the course of development, genetic factors may play a progressively more important role, while shared environmental effects might decrease. However, most of this literature is limited by low power, measurement issues, and cross-sectional design. The findings of molecular genetic studies are, overall, inconclusive. The literature on main genetic effects and gene-by-environment interactions on attachment is filled with inconsistent and unreplicated findings. Also, most studies are underpowered. Challenges for future research are to identify the unshared environmental mechanisms involved in shaping attachment, and to better elucidate the genes involved and their interaction with the environment. Some pioneer studies suggested that the incorporation of epigenetic processes into G × E interaction models might represent a promising future way for investigating the complex, dynamic interplay between genes, environment, and attachment.
在过去的二十年中,人们越来越关注分离遗传和环境因素对依恋个体差异的贡献,并确定参与塑造依恋的基因。双胞胎研究表明,随着依恋在发展过程中的变化,遗传因素可能发挥越来越重要的作用,而共同的环境影响可能会减少。然而,大多数此类文献的局限性在于低功效、测量问题和横断面设计。分子遗传学研究的结果总体上没有定论。关于主要遗传效应和基因-环境相互作用对依恋的文献充满了不一致和未经复制的发现。此外,大多数研究的功效都不足。未来研究的挑战是确定参与塑造依恋的非共享环境机制,并更好地阐明所涉及的基因及其与环境的相互作用。一些先驱性研究表明,将表观遗传过程纳入 G×E 相互作用模型可能代表了一种有前途的未来方法,可以研究基因、环境和依恋之间复杂、动态的相互作用。