Sofer S, Gueron M
Pediatric Intensive Care Unit, Ben-Gurion University, Beer-Sheva, Israel.
Toxicon. 1988;26(10):931-9. doi: 10.1016/0041-0101(88)90258-9.
Nine children, hospitalized for severe respiratory failure following scorpion envenomation, were a part of a group of 61 youngsters and infants admitted to the Pediatric Intensive Care Unit of the Soroka Medical Center, Beer-Sheva during the years 1983-87 because of scorpion venom intoxication. Four out of the nine had cardiogenic shock, three had severe systemic hypertension and one had severe airway obstruction. All nine patients had central nervous system manifestations, including lethargy, confusion and agitation (three cases), and markedly reduced level of consciousness (six cases). Hemodynamic studies performed in two patients showed 'high pressure' (cardiogenic) pulmonary edema. Seven patients recovered completely, one died and another one was left severely handicapped. Hydralazine i.v. showed a remarkable effect on the systemic blood pressure and central nervous system disturbances in addition to mechanical ventilation. Based on our own experience and previous clinical and experimental studies, the possible pathogenetic mechanisms underlying the respiratory and central nervous system dysfunction following scorpion sting are discussed.
1983年至1987年间，因蝎子蜇伤中毒而入住贝尔谢巴索罗卡医疗中心儿科重症监护病房的61名儿童和婴儿中，有9名因严重呼吸衰竭住院。这9名患儿中，4名发生心源性休克，3名出现严重全身性高血压，1名有严重气道梗阻。9名患者均有中枢神经系统表现，包括嗜睡、意识模糊和躁动（3例），以及意识水平明显降低（6例）。对2名患者进行的血流动力学研究显示为“高压性”（心源性）肺水肿。7名患者完全康复，1名死亡，另1名严重致残。静脉注射肼屈嗪除机械通气外，对全身血压和中枢神经系统紊乱显示出显著效果。基于我们自己的经验以及以往的临床和实验研究，讨论了蝎子蜇伤后呼吸和中枢神经系统功能障碍的可能发病机制。
