胃癌手术后吻合口漏对总生存和无病生存的影响：一项系统评价。
Impact of Anastomotic Leakage on Overall and Disease-free Survival After Surgery for Gastric Carcinoma: A Systematic Review.
机构信息
General Surgery Unit, Department of Medical and Surgical Sciences and Translational Medicine, St. Andrea University Hospital, Sapienza University of Rome, Rome, Italy.
General Surgery Unit, Department of Medical and Surgical Sciences and Translational Medicine, St. Andrea University Hospital, Sapienza University of Rome, Rome, Italy
出版信息
Anticancer Res. 2020 Feb;40(2):619-624. doi: 10.21873/anticanres.13991.
BACKGROUND/AIM: Gastric cancer is the fifth most frequently diagnosed cancer and the second most common cause of cancer-related death. The only potentially curative treatment is surgical resection, which is associated with potentially severe complications, such as anastomotic leakage. The aim of this systematic review was to evaluate the relationship between anastomotic leakage and overall and disease-free survival after surgery for gastric cancer.
MATERIALS AND METHODS
A systematic literature search was performed and 7 articles published between 2010 and 2019 were included, including a total of 7,167 patients.
RESULTS
Among the included studies the frequency of anastomotic leakage ranged from 6 to 41%. Patients affected by anastomotic leakage had an overall survival ranging between 4.1 and 97.6 months, whereas patients who did not experience anastomotic leakage had an overall survival between 23 and 109.5 months.
CONCLUSION
Closer follow-up or even more aggressive oncological therapy may be considered for patients affected by anastomotic leakage after surgery for gastric cancer.
背景/目的：胃癌是全球第五大常见癌症，也是癌症相关死亡的第二大主要原因。唯一潜在的治愈性治疗方法是手术切除，但该治疗方法与吻合口漏等严重并发症相关。本系统综述的目的是评估胃癌手术后吻合口漏与总生存和无病生存之间的关系。
材料与方法
进行了系统的文献检索，纳入了 2010 年至 2019 年发表的 7 篇文章，共纳入 7167 例患者。
结果
纳入的研究中，吻合口漏的发生率为 6%至 41%。发生吻合口漏的患者总生存时间为 4.1 至 97.6 个月，而未发生吻合口漏的患者总生存时间为 23 至 109.5 个月。
结论
对于接受胃癌手术后发生吻合口漏的患者，可能需要更密切的随访或更积极的肿瘤治疗。
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