培尼培南类似物增强克拉霉素和利福平对 -介导的多黏菌素耐药大肠杆菌的作用。
Paenipeptin Analogues Potentiate Clarithromycin and Rifampin against -Mediated Polymyxin-Resistant Escherichia coli .
机构信息
Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
出版信息
Antimicrob Agents Chemother. 2020 Mar 24;64(4). doi: 10.1128/AAC.02045-19.
Abstract
Polymyxin resistance mediated by the gene threatens the last-resort antibiotics. Linear lipopeptide paenipeptin analogues 1 and 15 disrupted the outer membrane of Gram-negative pathogens and potentiated clarithromycin and rifampin against -positive from the FDA-CDC Antimicrobial Resistance Isolate Bank. In the presence of paenipeptin, clarithromycin and rifampin resulted in over 3-log reduction of Moreover, paenipeptin-antibiotic combinations significantly reduced in a murine thigh infection model.
摘要
基因介导的多粘菌素耐药性威胁着最后一道抗生素防线。线性脂肽培尼培南类似物 1 和 15 破坏革兰氏阴性病原体的外膜，并增强克拉霉素和利福平对来自 FDA-CDC 抗菌药物耐药性分离库的阳性菌的作用。在培尼培南存在的情况下，克拉霉素和利福平使阳性菌的数量减少了 3 个对数级以上。此外，培尼培南-抗生素联合用药在小鼠大腿感染模型中显著减少了细菌负荷。
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