胃袖状切除术增加抗逆转录病毒药物暴露的病例报告。
Case Report of Increased Exposure to Antiretrovirals following Sleeve Gastrectomy.
机构信息
Department of Internal Medicine, Mt. Scopus Hospital, Hebrew University Hadassah Medical Center, Jerusalem, Israel
Hadassah AIDS Center, Department of Clinical Microbiology and Infectious Diseases, Hebrew University Hadassah Medical Center, Jerusalem, Israel.
出版信息
Antimicrob Agents Chemother. 2020 Mar 24;64(4). doi: 10.1128/AAC.02453-19.
Abstract
Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ∼12-fold. Several mechanistic explanations for these findings are discussed.
摘要
减重手术在病态肥胖的 HIV 患者中越来越多地进行。关于减重手术后抗逆转录病毒药物暴露的数据有限。我们报告了一例病态肥胖的 HIV 患者行胃袖状切除术的病例。在手术前后的多个时间点进行了阿巴卡韦、拉米夫定和度鲁特韦的治疗药物监测。测量到显著升高的水平，特别是阿巴卡韦，其水平增加了约 12 倍。讨论了这些发现的几种机制解释。
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