Porat Daniel, Dahan Arik
Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
J Clin Med. 2020 May 17;9(5):1511. doi: 10.3390/jcm9051511.
Substantially altered gastrointestinal anatomy/physiology after bariatric surgery presents new challenges for the proper medication management of these patients; drug absorption and bioavailability may increase, decrease, or remain unchanged post surgery, depending on the specific drug in question and the type of bariatric procedure. In this article, we offer a concise overview of the various aspects of this clinically significant issue, aiming to provide readers with a clear understanding as well as practical tools to handle drug management post bariatric surgery. Realizing the potentially altered pharmacokinetics of various drugs after bariatric surgery is essential for providing optimal pharmacological therapy and overall patient care.
减肥手术后胃肠道解剖结构/生理功能发生显著改变，给这些患者的合理药物管理带来了新挑战；术后药物吸收和生物利用度可能增加、降低或保持不变，这取决于所涉及的具体药物和减肥手术的类型。在本文中，我们简要概述了这个具有临床意义的问题的各个方面，旨在为读者提供清晰的理解以及处理减肥手术后药物管理的实用工具。认识到减肥手术后各种药物潜在的药代动力学改变对于提供最佳药物治疗和全面的患者护理至关重要。
