Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.
Translational Tissue Engineering Center, Baltimore, Maryland.
Cancer Res. 2020 Feb 1;80(3):377-378. doi: 10.1158/0008-5472.CAN-19-3631.
Synthetic biomaterials implanted in the body induce a foreign body reaction characterized by chronic inflammation and fibrosis. In this issue of , Oakes and colleagues used biomaterial implants and their associated immunologic activity to develop a "metastasis sensor" for detection of tumor burden at distal sites. A scoring system was developed from computational analysis of gene expression patterns from implant biopsies that could predict the presence of tumor. This unexpected use of biomaterials for early detection of cancer provides a more accurate systemic sampling compared with blood or liquid biopsies and alleviates the need for inefficient imaging and biopsy sampling from potential metastatic target tissues..
植入体内的合成生物材料会引发异物反应，其特征是慢性炎症和纤维化。在本期杂志中，奥克斯及其同事利用生物材料植入物及其相关免疫活性，开发了一种“转移传感器”，用于检测远处部位的肿瘤负担。通过对植入物活检的基因表达模式进行计算分析，开发了一种评分系统，该系统可以预测肿瘤的存在。与血液或液体活检相比，这种对癌症进行早期检测的生物材料的意外用途提供了更准确的系统采样，并减轻了对潜在转移靶组织进行低效成像和活检采样的需求。
