Department of Environmental Health, Exposure, Epidemiology, and Risk Program, Harvard T.H. Chan School of Public Health, Boston, USA.
Clinical Research Center, Soroka University Medical Center, Beer Sheba, Israel.
Sci Rep. 2020 Feb 3;10(1):1710. doi: 10.1038/s41598-020-58679-z.
Studies have shown stress may lead to diabetes-related morbidities. In recent years during enhanced hostility periods, the population of Southern Israel experienced alert sirens and rocket fire on a daily basis. We investigated whether the exposure to these stressful circumstances, which peaked during three large military operations (MO), was associated with increased glucose levels among the civilian population. We included all fasting serum glucose tests taken between 2007-2014, of Clalit Health Services members in Southern Israel who had at least one fasting glucose test during an MO period and at least one test drawn at other times. We analyzed the association between MO periods and glucose using linear mixed-effects models. We included 408,706 glucose tests (10% during MO periods). Among subjects who reside in proximity to Gaza, glucose levels were 2.10% (95% CI 1.24%; 2.97%) higher in MO days compared to other times. A weaker effect was observed among subjects in more remote locations. In conclusion, we found stress to be associated with increased fasting glucose levels, especially among those who reside in locations in which the intensity of the threat is higher. Since glucose may be a marker of the population at cardiovascular risk, further studies are required.
研究表明，压力可能导致与糖尿病相关的发病率。近年来，在敌对情绪加剧期间，以色列南部的居民每天都要面对警报声和火箭弹的袭击。我们调查了这些压力环境是否会导致平民的血糖水平升高，这些压力环境在三次大规模军事行动（MO）期间达到高峰。我们纳入了 2007 年至 2014 年间在以色列南部接受克拉利特健康服务（Clalit Health Services）的所有空腹血清葡萄糖检测，这些人在 MO 期间至少进行了一次空腹血糖检测，并且在其他时间至少进行了一次检测。我们使用线性混合效应模型分析了 MO 期间与血糖之间的关联。我们纳入了 408706 次葡萄糖检测（10%在 MO 期间）。在靠近加沙的居民中，MO 期间的血糖水平比其他时间高 2.10%（95%CI 1.24%；2.97%）。在位置较偏远的居民中，这种影响较弱。总之，我们发现压力与空腹血糖水平升高有关，尤其是在那些居住在威胁强度更高的地方的居民中。由于葡萄糖可能是心血管风险人群的标志物，因此需要进一步研究。
