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高水平慢性应激导致的血糖生成的实用量化。

A practical quantification of blood glucose production due to high-level chronic stress.

机构信息

Centre for Research and Continued Engineering Development, North-West University, Lynnwood Ridge, South Africa.

出版信息

Stress Health. 2012 Oct;28(4):327-32. doi: 10.1002/smi.2415. Epub 2011 Dec 28.

DOI:10.1002/smi.2415
PMID:22223631
Abstract

Blood glucose (BG) is the primary metabolic fuel for, among others, cancer cell progression, cardiovascular disease and inflammation. Stress is an important contributor to the amount of BG produced especially by the liver. In this paper, we attempt to quantify the BG production due to chronic (in the order of weeks) high-level psychological stress in a manner that a lay person will understand. Three independent approaches were used. The first approach was based on a literature survey of stress hormone data from healthy individuals and its subsequent mathematical manipulation. The next approach was a deductive process where BG levels could be deduced from published stress data of large cardiovascular clinical trials. The third approach used empirical BG data and a BG simulation model. The three different methods produced an average BG increase of 2.2-fold above basal for high levels of stress over a period of more than a day. The standard deviation normalized to the average value was 4.5%.

摘要

血糖(BG)是癌症细胞进展、心血管疾病和炎症等的主要代谢燃料。压力是肝脏产生 BG 的主要因素之一。在本文中,我们试图以一种外行人能够理解的方式量化由于慢性(数周)高水平心理压力导致的 BG 产生。我们使用了三种独立的方法。第一种方法基于对健康个体的应激激素数据的文献调查及其随后的数学处理。第二种方法是一种演绎过程,可以从已发表的大型心血管临床试验的应激数据中推断出 BG 水平。第三种方法使用了经验性的 BG 数据和 BG 模拟模型。这三种不同的方法产生了平均 BG 增加了 2.2 倍,高于高水平压力超过一天的基础水平。标准差相对于平均值的归一化值为 4.5%。

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