University of Wisconsin-Madison Department of Neurology, Madison, Wisconsin, 53705, USA.
University of Wisconsin-Madison Department of Psychiatry, Madison, Wisconsin, 53705, USA.
Sci Rep. 2020 Feb 3;10(1):1673. doi: 10.1038/s41598-020-58612-4.
In this study, we applied high-density EEG recordings (HD-EEG) to quantitatively characterize the fine-grained spatiotemporal distribution of inter-ictal epileptiform discharges (IEDs) across different sleep stages. We quantified differences in spatial extent and duration of IEDs at the scalp and cortical levels using HD-EEG source-localization, during non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep, in six medication-refractory focal epilepsy patients during epilepsy monitoring unit admission. Statistical analyses were performed at single subject level and group level across different sleep stages for duration and distribution of IEDs. Tests were corrected for multiple comparisons across all channels and time points. Compared to NREM sleep, IEDs during REM sleep were of significantly shorter duration and spatially more restricted. Compared to NREM sleep, IEDs location in REM sleep also showed a higher concordance with electrographic ictal onset zone from scalp EEG recording. This study supports the localizing value of REM IEDs over NREM IEDs and suggests that HD-EEG may be of clinical utility in epilepsy surgery work-up.
在这项研究中，我们应用高密度脑电图记录（HD-EEG）来定量描述发作间期癫痫样放电（IED）在不同睡眠阶段的精细时空分布。我们使用 HD-EEG 源定位，在 6 名药物难治性局灶性癫痫患者癫痫监测单元入院期间的非快速眼动（NREM）睡眠和快速眼动（REM）睡眠期间，量化头皮和皮质水平上 IED 的空间范围和持续时间的差异。在不同的睡眠阶段，在单个体水平和组水平上对 IED 的持续时间和分布进行了统计分析。对所有通道和时间点的多次比较进行了校正。与 NREM 睡眠相比，REM 睡眠中的 IED 持续时间明显更短，空间上更受限。与 NREM 睡眠相比，REM 睡眠中的 IED 位置与头皮 EEG 记录的电发作起始区也具有更高的一致性。这项研究支持 REM IED 比 NREM IED 具有更好的定位价值，并表明高密度脑电图在癫痫手术评估中可能具有临床应用价值。
