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外胚层发育不良患者唾液流速和抗氧化剂水平的评估：一项研究。

Assessment of Salivary Flow Rate and Antioxidant Levels in Ectodermal Dysplasia Patients: An Study.

作者信息

Mohanan Aravind, Varma Balagopal R, Kumar Suresh, Kumaran Parvathy, Xavier Arun Mamachan

机构信息

Department of Pedodontics and Preventive Dentistry, Amrita Institute of Medical Science, Kochi, Kerala, India.

出版信息

Contemp Clin Dent. 2019 Jan-Mar;10(1):74-80. doi: 10.4103/ccd.ccd_358_18.

DOI:10.4103/ccd.ccd_358_18
PMID:32015646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6975008/
Abstract

AIMS

To assess the salivary flow rate levels and total antioxidant levels in ectodermal dysplasia (ED) patients and to compare with normal individuals.

MATERIALS AND METHODS

Unstimulated saliva sample of control and case were collected from the mouth to a pre-weighed Eppendorf tube using a Pasteur pipette for 4 min. Stimulated saliva of case and control was also collected after chewing paraffin wax for 30 s. Both the Eppendorf tubes were weighed again after collection of both the saliva samples. The flow rate was calculated as difference of weight of the tube divided by time (4 min). Both unstimulated and stimulated saliva was also separately collected for estimation for total antioxidant levels.

STATISTICAL ANALYSIS

For intergroup comparison, Mann-Whitney test was used, and for intragroup comparison, Wilcoxon signed-rank test was used.

RESULTS

In the intergroup comparison of both the salivary flow rate and total antioxidant levels, there was no statistically significant difference; however, there was statistically significant difference in the intragroup comparison of salivary flow rate and total antioxidant levels in case group.

CONCLUSIONS

There was a diminished unstimulated salivary flow rate in ED group, but stimulated salivary flow rate was significantly high and the total antioxidant levels in unstimulated saliva of the case group were significantly higher than the stimulated antioxidant levels.

摘要

目的

评估外胚层发育不良（ED）患者的唾液流速水平和总抗氧化剂水平，并与正常个体进行比较。

材料与方法

使用巴氏吸管从对照组和病例组的口腔中收集未刺激唾液样本至预先称重的微量离心管中，持续4分钟。病例组和对照组在咀嚼石蜡30秒后也收集刺激唾液。收集完两种唾液样本后，再次称量微量离心管。流速计算为管重量的差值除以时间（4分钟）。还分别收集未刺激和刺激唾液以评估总抗氧化剂水平。

统计分析

组间比较采用曼-惠特尼检验，组内比较采用威尔科克森符号秩检验。

结果

在唾液流速和总抗氧化剂水平的组间比较中，无统计学显著差异；然而，病例组在唾液流速和总抗氧化剂水平的组内比较中有统计学显著差异。

结论

ED组未刺激唾液流速降低，但刺激唾液流速显著升高，且病例组未刺激唾液中的总抗氧化剂水平显著高于刺激后的抗氧化剂水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/6975008/5560be22c81b/CCD-10-74-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/6975008/f5743f0a57e0/CCD-10-74-g008.jpg
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