Department of Anorectal Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.
Dis Markers. 2020 Jan 16;2020:9026707. doi: 10.1155/2020/9026707. eCollection 2020.
As an important component of miRNA processing genes, RAN gene encodes the ras-related nuclear protein, which is a unique member of the Ras superfamily of GTPases. The mutations in RAN gene are very likely to play a critical role in pathology-related changes to miRNA transport and expression and thus participate in tumor genesis and development. Currently, accumulating studies have explored the association between RAN SNPs and cancer risk. However, the results are conflicting. In the present study, we performed a systematic review for the association of RAN SNPs with overall cancer risk. Meanwhile, a meta-analysis was conducted based on available data, aiming at clarifying the association between RAN SNPs and cancer susceptibility. After literature search and data extraction, 17 studies containing four RAN SNPs were involved in the systematic review. And 12 studies with two highly studied SNPs (RAN rs14035 C>T and rs3803012 A>G) were included in the final meta-analysis, consisting of 7662 cases and 9807 controls. The results showed that the rs14035 polymorphism was linked to a decreased cancer risk in overall subjects and hospital-based (HB) subgroup, while the rs3803012 polymorphism conferred to an increased cancer risk in overall subjects and population-based (PB) subgroup. Our findings suggested that the two SNPs had the potential to be predictive biomarkers for cancer risk. The study would provide novel clues for the identification of miRNA-related genetic biomarkers applied to predicting cancer susceptibility.
作为 miRNA 加工基因的重要组成部分，RAN 基因编码 Ras 相关核蛋白，它是 Ras 家族 GTP 酶的独特成员。RAN 基因的突变很可能在 miRNA 转运和表达的病理学相关变化中发挥关键作用，从而参与肿瘤的发生和发展。目前，越来越多的研究探讨了 RAN SNPs 与癌症风险之间的关联。然而，结果却存在矛盾。在本研究中，我们对 RAN SNPs 与总体癌症风险之间的关联进行了系统评价。同时，基于现有数据进行了荟萃分析，旨在阐明 RAN SNPs 与癌症易感性之间的关联。经过文献检索和数据提取，共有 17 项研究包含四个 RAN SNPs 纳入了系统评价。最终荟萃分析纳入了 12 项研究，其中包括两个高度研究的 SNPs（RAN rs14035 C>T 和 rs3803012 A>G），共包含 7662 例病例和 9807 例对照。结果表明，rs14035 多态性与总体和医院人群（HB）亚组的癌症风险降低相关，而 rs3803012 多态性与总体和人群（PB）亚组的癌症风险增加相关。我们的研究结果表明，这两个 SNP 可能是癌症风险的预测生物标志物。该研究为鉴定 miRNA 相关遗传生物标志物应用于预测癌症易感性提供了新的线索。
