Department of Anorectal Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China.
Department of Anorectal Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China
Biosci Rep. 2017 Nov 23;37(6). doi: 10.1042/BSR20171121. Print 2017 Dec 22.
CTNNB1, encoding β-catenin, is a well-known tumor-related gene in the wnt signaling pathway. It has been reported that CTNNB1 polymorphisms are associated with cancer risk. However, the data were inconsistent. In this article, we conducted a systematic review for the researches related to the association of single nucleotide polymorphisms (SNPs) in CTNNB1 with overall cancer risk. Meanwhile, a series of inclusion and exclusion criteria were set to select articles for quantitative analysis. Consequently, eight case-control studies containing 4388 cases and 4477 controls were included in a meta-analysis of four highly studied CTNNB1 SNPs (rs1798802 A/G, rs4135385 A/G, rs11564475 A/G, and rs2293303 C/T). The association between each SNP and cancer risk was estimated by calculating odds ratios (ORs) and their 95% confidence intervals (95%CIs). The results showed rs1798802 (AA compared with GG: =0.044, OR=0.72) and rs2293303 (TT compared with CC: =0.002, OR=2.86; recessive model: =0.006, OR=2.91; T compared with C: =0.004, OR=1.19) polymorphisms were associated with overall cancer risk. In stratified analysis, rs4135385 polymorphism was found to elevate the risk in Caucasian or in gastrointestinal cancer subgroup. Additionally, rs2293303 conferred to an increased cancer risk when the source of control groups was hospital-based (HB). In conclusion, the three CTNNB1 SNPs were suggested to have the potential to be novel biomarkers for risk prediction of cancer in overall population or some specific subgroups. Our study could provide research clues for further related investigations.
CTNNB1，编码β-连环蛋白，是 Wnt 信号通路中一个众所周知的肿瘤相关基因。已有报道称，CTNNB1 多态性与癌症风险相关。然而，数据并不一致。在本文中，我们对与 CTNNB1 单核苷酸多态性（SNP）与总体癌症风险相关的研究进行了系统评价。同时，我们设定了一系列纳入和排除标准，以选择用于定量分析的文章。因此，有 8 项病例对照研究共纳入了 4388 例病例和 4477 例对照，对其中 4 个研究较多的 CTNNB1 SNP（rs1798802A/G、rs4135385A/G、rs11564475A/G 和 rs2293303C/T）进行了荟萃分析。通过计算比值比（OR）及其 95%置信区间（95%CI）来估计每个 SNP 与癌症风险的关系。结果显示，rs1798802（AA 与 GG 相比：=0.044，OR=0.72）和 rs2293303（TT 与 CC 相比：=0.002，OR=2.86；隐性模型：=0.006，OR=2.91；T 与 C 相比：=0.004，OR=1.19）多态性与总体癌症风险相关。分层分析显示，rs4135385 多态性增加了白种人和胃肠道癌症亚组的风险。此外，当对照组的来源为医院时（HB），rs2293303 多态性增加了癌症风险。总之，这 3 个 CTNNB1 SNP 可能成为总体人群或某些特定亚组癌症风险预测的新型生物标志物。我们的研究为进一步的相关研究提供了研究线索。
