中国人群中 miRNA 生物发生基因 RAN、DICER 和 HIWI 的遗传变异与宫颈癌风险。
Genetic variants in RAN, DICER and HIWI of microRNA biogenesis genes and risk of cervical carcinoma in a Chinese population.
机构信息
State Key Laboratory of Reproductive Medicine, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China; ; Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing 210029, China;
出版信息
Chin J Cancer Res. 2013 Oct;25(5):565-71. doi: 10.3978/j.issn.1000-9604.2013.10.03.
OBJECTIVE
Recent evidence indicates that dysregulation of microRNA (miRNA) biogenesis is implicated in cancer development and progression. Based on the important role of miRNA biogenesis genes in carcinogenesis, we hypothesized that genetic variations of the miRNA biogenesis genes may modulate susceptibility to cervical cancer.
METHODS
We identified three single nucleotide polymorphisms (SNPs) located in the 3'-untranslated regions (3'-UTR) of of miRNA biogenesis key genes (rs1057035 in DICER, rs3803012 in RAN and rs10773771 in HIWI) and genotyped these SNPs in a case-control study of 1,486 cervical cancer cases and 1,549 cancer-free controls in Chinese women.
RESULTS
Logistic regression analyses showed that no significant associations were observed between the three SNPs and cervical cancer risk [rs3803012 in RAN AG/GG vs. AA adjusted OR =1.104, 95% confidence interval (CI): 0.859-1.419; rs1057035 in DICER CT/CC vs. TT adjusted OR =0.962, 95% CI: 0.805-1.149; rs10773771 in HIWI CT/CC vs. TT adjusted OR =0.963, 95% CI: 0.826-1.122].
CONCLUSIONS
The findings did not suggest that genetic variants in the 3'-UTR of RAN, DICER and HIWI of miRNA biogenesis genes were associated with the risk of cervical cancer in this Chinese population.
目的
最近的证据表明，miRNA（miRNA）生物发生的失调与癌症的发生和发展有关。基于 miRNA 生物发生基因在致癌作用中的重要作用，我们假设 miRNA 生物发生基因的遗传变异可能调节宫颈癌的易感性。
方法
我们鉴定了位于 miRNA 生物发生关键基因 3'-非翻译区（3'-UTR）中的三个单核苷酸多态性（SNP）（DICER 中的 rs1057035、RAN 中的 rs3803012 和 HIWI 中的 rs10773771），并在一项中国女性宫颈癌病例对照研究中对这些 SNP 进行了基因分型。
结果
逻辑回归分析显示，三个 SNP 与宫颈癌风险之间没有显著关联[RAN 中的 rs3803012 AG/GG 与 AA 调整后的 OR=1.104，95%置信区间（CI）：0.859-1.419；DICER 中的 rs1057035 CT/CC 与 TT 调整后的 OR=0.962，95% CI：0.805-1.149；HIWI 中的 rs10773771 CT/CC 与 TT 调整后的 OR=0.963，95% CI：0.826-1.122]。
结论
在该中国人群中，miRNA 生物发生基因 3'-UTR 中的遗传变异与宫颈癌风险无关。
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