• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Genetic variants in RAN, DICER and HIWI of microRNA biogenesis genes and risk of cervical carcinoma in a Chinese population.中国人群中 miRNA 生物发生基因 RAN、DICER 和 HIWI 的遗传变异与宫颈癌风险。
Chin J Cancer Res. 2013 Oct;25(5):565-71. doi: 10.3978/j.issn.1000-9604.2013.10.03.
2
Potentially functional genetic variants in microRNA processing genes and risk of HBV-related hepatocellular carcinoma.miRNA 加工基因中潜在功能的遗传变异与 HBV 相关肝细胞癌的风险。
Mol Carcinog. 2013 Nov;52 Suppl 1:E148-54. doi: 10.1002/mc.22062. Epub 2013 Jul 19.
3
Genetic variant in DICER gene is associated with prognosis of hepatocellular carcinoma in a Chinese cohort.DICER基因的遗传变异与中国人群队列中肝细胞癌的预后相关。
Hepatol Res. 2017 Aug;47(9):845-853. doi: 10.1111/hepr.12824. Epub 2016 Nov 7.
4
Genetic variations in key microRNA processing genes and risk of head and neck cancer: a case-control study in Chinese population.关键 miRNA 加工基因的遗传变异与头颈部癌症风险：中国人群的病例对照研究。
PLoS One. 2012;7(10):e47544. doi: 10.1371/journal.pone.0047544. Epub 2012 Oct 11.
5
Genetic variants in microRNA machinery genes are associated [corrected] with idiopathic recurrent pregnancy loss risk.微小RNA机制基因中的遗传变异与特发性复发性流产风险相关[已修正]。
PLoS One. 2014 Apr 25;9(4):e95803. doi: 10.1371/journal.pone.0095803. eCollection 2014.
6
Genetic variants in DICER1, DROSHA, RAN, and XPO5 genes and risk of pregnancy-induced hypertension.DICER1、DROSHA、RAN 和 XPO5 基因中的遗传变异与妊娠高血压的风险。
Pregnancy Hypertens. 2019 Apr;16:161-166. doi: 10.1016/j.preghy.2019.04.005. Epub 2019 Apr 16.
7
Common genetic polymorphisms of microRNA biogenesis pathway genes and risk of breast cancer: a case-control study in Korea.常见 miRNA 生物发生途径基因的遗传多态性与乳腺癌风险：韩国的病例对照研究。
Breast Cancer Res Treat. 2011 Dec;130(3):939-51. doi: 10.1007/s10549-011-1656-2. Epub 2011 Jul 16.
8
[The Association Between the Polymorphisms of miRNA Biogenesis Related Genes( and )and Unexplained Recurrent Spontaneous Abortion in Chinese Women].[微小RNA生物合成相关基因多态性与中国女性不明原因复发性自然流产的关联]
Sichuan Da Xue Xue Bao Yi Xue Ban. 2017 Nov;48(6):880-885.
9
Association of MicroRNA Biogenesis Genes Polymorphisms with Risk of Large Artery Atherosclerosis Stroke.微小 RNA 生物发生基因多态性与大动脉粥样硬化性脑卒中风险的关联。
Cell Mol Neurobiol. 2022 Aug;42(6):1801-1807. doi: 10.1007/s10571-021-01057-8. Epub 2021 Feb 23.
10
Association of MicroRNA Biogenesis Genes Polymorphisms with Ischemic Stroke Susceptibility and Post-Stroke Mortality.微小RNA生物合成基因多态性与缺血性中风易感性及中风后死亡率的关联
J Stroke. 2018 Jan;20(1):110-121. doi: 10.5853/jos.2017.02586. Epub 2018 Jan 31.

引用本文的文献

1
Molecular interaction of human papilloma virus (HPV) with microRANs: insights into the development of cervical cancer and treatment approaches.人乳头瘤病毒（HPV）与微小RNA的分子相互作用：对宫颈癌发展及治疗方法的见解
Infect Agent Cancer. 2025 Jul 23;20(1):49. doi: 10.1186/s13027-025-00677-9.
2
Pan-Cancer Study on Variants of Canonical miRNA Biogenesis Pathway Components: A Pooled Analysis.经典miRNA生物合成途径成分变异的泛癌研究：一项汇总分析
Cancers (Basel). 2023 Jan 4;15(2):338. doi: 10.3390/cancers15020338.
3
Relationship between the Occurrence of Genetic Variants of Single Nucleotide Polymorphism in microRNA Processing Genes and the Risk of Developing Multiple Sclerosis.微小RNA加工基因中单核苷酸多态性遗传变异的发生与多发性硬化症发病风险之间的关系。
Biomedicines. 2022 Dec 3;10(12):3124. doi: 10.3390/biomedicines10123124.
4
Association of microRNA biosynthesis genes XPO5 and RAN polymorphisms with cancer susceptibility: Bayesian hierarchical meta-analysis.微小RNA生物合成基因XPO5和RAN多态性与癌症易感性的关联：贝叶斯分层荟萃分析
J Cancer. 2020 Feb 3;11(8):2181-2191. doi: 10.7150/jca.37150. eCollection 2020.
5
A Systematic Review and Meta-Analysis for the Association of Gene Polymorphisms in RAN with Cancer Risk.RAN 基因多态性与癌症风险关联的系统评价和荟萃分析。
Dis Markers. 2020 Jan 16;2020:9026707. doi: 10.1155/2020/9026707. eCollection 2020.
6
Single nucleotide polymorphisms in piRNA-pathway genes: an insight into genetic determinants of human diseases.piRNA 通路基因中的单核苷酸多态性：人类疾病遗传决定因素的新视角。
Mol Genet Genomics. 2020 Jan;295(1):1-12. doi: 10.1007/s00438-019-01612-5. Epub 2019 Oct 14.
7
Analysis of the Association Between MicroRNA Biogenesis Gene Polymorphisms and Venous Thromboembolism in Koreans.分析 miRNA 生物发生基因多态性与韩国人静脉血栓栓塞的关系。
Int J Mol Sci. 2019 Aug 1;20(15):3771. doi: 10.3390/ijms20153771.
8
Association of variants of miRNA processing genes with cervical precancerous lesion risk in a southern Chinese population.miRNA 加工基因变异与中国南方人群宫颈癌前病变风险的关联。
Biosci Rep. 2018 May 31;38(3). doi: 10.1042/BSR20171565. Print 2018 Jun 29.
9
Association of miRNA biosynthesis genes and polymorphisms with cancer susceptibility: a systematic review and meta-analysis.miRNA 生物合成基因与癌症易感性的关联：系统评价和荟萃分析。
Biosci Rep. 2018 Jun 27;38(3). doi: 10.1042/BSR20180072. Print 2018 Jun 29.
10
MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis.微小RNA生物合成途径基因多态性与癌症风险：一项系统综述和荟萃分析
PeerJ. 2016 Dec 7;4:e2706. doi: 10.7717/peerj.2706. eCollection 2016.

本文引用的文献

1
Dysregulated expression of dicer and drosha in breast cancer.乳腺癌中 dicer 和 drosha 的表达失调。
Pathol Oncol Res. 2012 Apr;18(2):343-8. doi: 10.1007/s12253-011-9450-3. Epub 2011 Sep 7.
2
Common genetic polymorphisms of microRNA biogenesis pathway genes and risk of breast cancer: a case-control study in Korea.常见 miRNA 生物发生途径基因的遗传多态性与乳腺癌风险：韩国的病例对照研究。
Breast Cancer Res Treat. 2011 Dec;130(3):939-51. doi: 10.1007/s10549-011-1656-2. Epub 2011 Jul 16.
3
Worldwide burden of cervical cancer in 2008.2008 年全球宫颈癌负担。
Ann Oncol. 2011 Dec;22(12):2675-2686. doi: 10.1093/annonc/mdr015. Epub 2011 Apr 6.
4
Overexpression of Dicer predicts poor survival in colorectal cancer.Dicer 过表达预示结直肠癌患者预后不良。
Eur J Cancer. 2011 Jun;47(9):1414-9. doi: 10.1016/j.ejca.2011.01.006. Epub 2011 Feb 21.
5
An essential role for Ran GTPase in epithelial ovarian cancer cell survival.Ran GTPase 在卵巢上皮性癌细胞存活中起关键作用。
Mol Cancer. 2010 Oct 13;9:272. doi: 10.1186/1476-4598-9-272.
6
Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.AGO1 基因常见变异与肺癌风险的关联：一项两阶段病例对照研究。
Mol Carcinog. 2010 Oct;49(10):913-21. doi: 10.1002/mc.20672.
7
Genetic variation in microRNA networks: the implications for cancer research.miRNA 网络中的遗传变异：对癌症研究的影响。
Nat Rev Cancer. 2010 Jun;10(6):389-402. doi: 10.1038/nrc2867.
8
The universal overexpression of a cancer testis antigen hiwi is associated with cancer angiogenesis.普遍过表达癌症睾丸抗原 hiwi 与癌症血管生成有关。
Oncol Rep. 2010 Apr;23(4):1063-8.
9
Expression of HIWI in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis.HIWI 在人食管鳞癌中的表达与更差的预后显著相关。
BMC Cancer. 2009 Dec 8;9:426. doi: 10.1186/1471-2407-9-426.
10
Genetic variation in MicroRNA genes and risk of oral premalignant lesions.miRNA 基因遗传变异与口腔癌前病变风险
Mol Carcinog. 2010 Feb;49(2):183-9. doi: 10.1002/mc.20588.

中国人群中 miRNA 生物发生基因 RAN、DICER 和 HIWI 的遗传变异与宫颈癌风险。

Genetic variants in RAN, DICER and HIWI of microRNA biogenesis genes and risk of cervical carcinoma in a Chinese population.

机构信息

State Key Laboratory of Reproductive Medicine, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China; ; Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing 210029, China;

出版信息

Chin J Cancer Res. 2013 Oct;25(5):565-71. doi: 10.3978/j.issn.1000-9604.2013.10.03.

DOI:10.3978/j.issn.1000-9604.2013.10.03
PMID:24255581
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3828428/
Abstract

OBJECTIVE

Recent evidence indicates that dysregulation of microRNA (miRNA) biogenesis is implicated in cancer development and progression. Based on the important role of miRNA biogenesis genes in carcinogenesis, we hypothesized that genetic variations of the miRNA biogenesis genes may modulate susceptibility to cervical cancer.

METHODS

We identified three single nucleotide polymorphisms (SNPs) located in the 3'-untranslated regions (3'-UTR) of of miRNA biogenesis key genes (rs1057035 in DICER, rs3803012 in RAN and rs10773771 in HIWI) and genotyped these SNPs in a case-control study of 1,486 cervical cancer cases and 1,549 cancer-free controls in Chinese women.

RESULTS

Logistic regression analyses showed that no significant associations were observed between the three SNPs and cervical cancer risk [rs3803012 in RAN AG/GG vs. AA adjusted OR =1.104, 95% confidence interval (CI): 0.859-1.419; rs1057035 in DICER CT/CC vs. TT adjusted OR =0.962, 95% CI: 0.805-1.149; rs10773771 in HIWI CT/CC vs. TT adjusted OR =0.963, 95% CI: 0.826-1.122].

CONCLUSIONS

The findings did not suggest that genetic variants in the 3'-UTR of RAN, DICER and HIWI of miRNA biogenesis genes were associated with the risk of cervical cancer in this Chinese population.

摘要

目的

最近的证据表明，miRNA（miRNA）生物发生的失调与癌症的发生和发展有关。基于 miRNA 生物发生基因在致癌作用中的重要作用，我们假设 miRNA 生物发生基因的遗传变异可能调节宫颈癌的易感性。

方法

我们鉴定了位于 miRNA 生物发生关键基因 3'-非翻译区（3'-UTR）中的三个单核苷酸多态性（SNP）（DICER 中的 rs1057035、RAN 中的 rs3803012 和 HIWI 中的 rs10773771），并在一项中国女性宫颈癌病例对照研究中对这些 SNP 进行了基因分型。

结果

逻辑回归分析显示，三个 SNP 与宫颈癌风险之间没有显著关联[RAN 中的 rs3803012 AG/GG 与 AA 调整后的 OR=1.104，95%置信区间（CI）：0.859-1.419；DICER 中的 rs1057035 CT/CC 与 TT 调整后的 OR=0.962，95% CI：0.805-1.149；HIWI 中的 rs10773771 CT/CC 与 TT 调整后的 OR=0.963，95% CI：0.826-1.122]。

结论

在该中国人群中，miRNA 生物发生基因 3'-UTR 中的遗传变异与宫颈癌风险无关。