Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, Canoas 100, Col. Los Angeles, 34067, Durango, DGO, Mexico.
Hormone Laboratory, Faculty of Medicine, University of San Luis Potosí, San Luis Potosí, Mexico.
Eur J Pediatr. 2020 Jun;179(6):953-958. doi: 10.1007/s00431-020-03570-2. Epub 2020 Feb 3.
It has been suggested that the triglyceride and glucose (TyG) index is an early indicator for type 2 diabetes (T2D) in adults. Thus, the aim of this study was to evaluate whether the TyG index is useful in the screening of glucose disorders (GD) in apparently healthy children and adolescents. Eligible participants were apparently healthy children and adolescents. Individuals with new diagnosis of GD were allocated into the study groups with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and T2D. Participants with normal glucose tolerance (NGT) were the control group. In total, 1872 children and adolescents were enrolled and allocated into the study groups. Diagnosis of NGT, IFG, IGT, and T2D was established in 1541 (82.3%), 256 (13.7%), 66 (3.5%), and 9 (0.4%) children, respectively. In girls, the best cutoff points of the TyG index for identifying IFG, IGT, and T2D were 4.51 (sensitivity 59.8%, specificity 59.8%), 4.55 (sensitivity 63.0%, specificity 64.3%), and 4.63 (sensitivity 75.0%, specificity 74.6%), respectively; and in boys were 4.52 (sensitivity 62.8%, specificity 64.2%), 4.54 (sensitivity 71.8%, specificity 65.1%), and 4.82 (sensitivity 91.0%, specificity 990.6%), respectively.Conclusion: Our results suggest that the TyG index may be a useful tool for screening GD in healthy children and adolescents.What is Known:• Prevalence of prediabetes and type 2 diabetes is increasing worldwide among young adults and adolescents.• Elevated fasting glucose and triglyceride concentrations have been recognized as independent risk factors for type 2 diabetes.What is New:• The TyG index exhibited highest sensitivity and specificity to detect impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes.• The TyG index may be a useful tool for the screening of glucose disorders in apparently healthy children and adolescents.
有人提出，三酰甘油和葡萄糖（TyG）指数是成人 2 型糖尿病（T2D）的早期指标。因此，本研究旨在评估 TyG 指数在筛查貌似健康的儿童和青少年葡萄糖紊乱（GD）中的作用。
合格的参与者为貌似健康的儿童和青少年。新诊断为 GD 的个体被分配到空腹血糖受损（IFG）、葡萄糖耐量受损（IGT）和 T2D 研究组。糖耐量正常（NGT）的参与者为对照组。共纳入 1872 例儿童和青少年，并将其分配到研究组。NGT、IFG、IGT 和 T2D 的诊断分别在 1541 例（82.3%）、256 例（13.7%）、66 例（3.5%）和 9 例（0.4%）儿童中确立。在女孩中，TyG 指数识别 IFG、IGT 和 T2D 的最佳截断点分别为 4.51（灵敏度 59.8%，特异性 59.8%）、4.55（灵敏度 63.0%，特异性 64.3%）和 4.63（灵敏度 75.0%，特异性 74.6%）；在男孩中，分别为 4.52（灵敏度 62.8%，特异性 64.2%）、4.54（灵敏度 71.8%，特异性 65.1%）和 4.82（灵敏度 91.0%，特异性 990.6%）。
我们的结果表明，TyG 指数可能是筛查健康儿童和青少年 GD 的有用工具。
全世界年轻人和青少年的糖尿病前期和 2 型糖尿病的患病率正在上升。
空腹血糖和甘油三酯浓度升高已被认为是 2 型糖尿病的独立危险因素。
TyG 指数对检测空腹血糖受损、葡萄糖耐量受损和 2 型糖尿病具有最高的灵敏度和特异性。
TyG 指数可能是筛查貌似健康的儿童和青少年葡萄糖紊乱的有用工具。
