Department of Women's and Children's Health, University of Padova, Padova, Italy.
Città della Speranza, Institute of Pediatric Research, Padova, Italy.
Pediatr Allergy Immunol. 2020 Feb;31 Suppl 24:16-18. doi: 10.1111/pai.13157.
Chronic obstructive respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD) have their roots in the womb. Together with a genetic predisposition, prenatal and early-life factors, including maternal smoking, prematurity, and bronchopulmonary dysplasia (BPD), have a pivotal role in later respiratory health. Then, inappropriate responses to respiratory viruses (especially respiratory syncytial virus and rhinovirus) and early allergic sensitization are the strongest contributors to the inception of wheezing and early-onset asthma. There is an urgent need for early disease biomarkers to identify profiles at higher risk of chronic respiratory conditions. Applying the "-omic" technologies to urine, blood and breath condensate, and non-invasive inflammometry seem promising in this regard. The description of specific risk profiles may be the key to the use of targeted personalized therapies.
慢性阻塞性呼吸系统疾病，如哮喘和慢性阻塞性肺疾病（COPD），其根源可追溯到子宫内。除了遗传易感性之外，产前和生命早期的因素，包括母亲吸烟、早产和支气管肺发育不良（BPD），在以后的呼吸健康中起着关键作用。然后，对呼吸道病毒（特别是呼吸道合胞病毒和鼻病毒）的不当反应以及早期过敏致敏是引发喘息和早发哮喘的最强因素。迫切需要早期疾病生物标志物来识别患有慢性呼吸道疾病风险较高的人群。在这方面，应用“组学”技术于尿液、血液和呼吸冷凝物，以及非侵入性炎症测量似乎很有前景。描述特定的风险概况可能是使用靶向个体化治疗的关键。
