Hansen S, Strøm M, Olsen S F, Dahl R, Hoffmann H J, Granström C, Rytter D, Bech B H, Linneberg A, Maslova E, Kiviranta H, Rantakokko P, Halldorsson T I
Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Clin Exp Allergy. 2016 Feb;46(2):329-36. doi: 10.1111/cea.12631.
Prenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine the associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year-old offspring.
In a Danish cohort of 965 pregnant women established in 1988-1989, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p'-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n = 872). Among those with available maternal exposure information, at age 20, 421 offspring attended attended a clinical examination including measurements of allergic sensitization (serum-specific IgE ≥ 0.35 kUA /L) (n = 418) and lung function [forced expiratory volume in one second (FEV1 ) and forced vital capacity (FVC)] (n = 414).
There were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV1 /FVC < 75%). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95% CI: 1.14-7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p'-DDE were 2.68 (1.06-6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV1 % of predicted value < 90%).
Our data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20 years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life.
孕期暴露于持久性有机污染物（POPs）与哮喘药物使用及自我报告症状有关，但与肺功能和过敏致敏的关联研究较少。本研究旨在探讨孕期暴露于POPs与20岁子代的过敏致敏及肺功能之间的关联。
在1988 - 1989年建立的一个包含965名丹麦孕妇的队列中，对孕30周采集的存档母血（n = 872）中的六种多氯联苯（PCB）同系物、六氯苯（HCB）和二氯二苯二氯乙烯（p,p'-DDE）进行定量分析。在有母亲暴露信息的子代中，421名20岁的子代参加了临床检查，包括测量过敏致敏情况（血清特异性IgE≥0.35 kUA/L）（n = 418）和肺功能[一秒用力呼气容积（FEV1）和用力肺活量（FVC）]（n = 414）。
母亲体内POPs浓度与子代20岁时的过敏致敏情况无关联。然而，母亲体内POPs浓度与子代气道阻塞（FEV1/FVC < 75%）呈正相关。与暴露水平处于第一三分位数的子代相比，暴露于类二噁英PCB第三三分位数的子代的比值比为2.96（95%可信区间：1.14 - 7.70）。非类二噁英PCB、HCB和p,p'-DDE的类似关联分别为2.68（1.06 - 6.81）、2.63（1.07, 6.46）和2.87（1.09, 7.57）。未观察到与肺功能降低（预测值的FEV1% < 90%）有关联。
我们的数据表明，孕期暴露于POPs似乎与20岁时的气道阻塞有关，但与过敏致敏无关。这些发现支持慢性阻塞性肺疾病可能至少部分起源于早年生活。
