Department of Health Policy, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Free Radic Biol Med. 2022 Aug 20;189:85-90. doi: 10.1016/j.freeradbiomed.2022.07.008. Epub 2022 Jul 19.
Childhood wheeze, asthma, and allergic rhinitis are common and likely have prenatal origins. Oxidative stress is associated with respiratory disease, but the association of oxidative stress during the prenatal period with development of respiratory and atopic disease in childhood, particularly beyond the infancy period, is unknown. This study aims to investigate associations between prenatal oxidative stress, measured by maternal urinary F-isoprostanes, and child respiratory outcomes, including effect modification by maternal race.
We prospectively studied Black (n = 717) and White (n = 363) mother-child dyads. We measured F-isoprostanes in 2nd-trimester urine (ng/mg-creatinine). At approximately age 4, we obtained parent report of provider-diagnosed asthma (ever), current wheeze, current asthma (diagnosis, symptoms and/or medication), and current allergic rhinitis (current defined as previous 12 months). We used multivariable logistic regression to estimate adjusted odds ratios (aOR) and 95% confidence intervals (95%CI) per interquartile range (IQR) increase in F-isoprostane concentration, controlling for confounders. We examined modification by maternal race using interaction terms.
The prevalence of provider-diagnosed asthma and current wheeze, asthma and allergic rhinitis was 14%, 19%, 15%, and 24%, respectively. Median (IQR) Fisoprostane levels were 2.1 (1.6, 2.9) ng/mg-creatinine. Associations between prenatal F-isoprostanes and provider-diagnosed asthma, current wheeze, and current asthma were modified by maternal race. Results were strongest for current wheeze (aOR [95%CI]: 1.55 [1.16, 2.06] for White; 0.98 [0.78, 1.22] for Black; p-interaction = 0.01). We observed no association between Fisoprostanes and allergic rhinitis.
Prenatal urinary F-isoprostanes may be a marker associated with childhood wheeze/asthma in certain populations. Research is needed to understand underlying mechanisms and racial differences.
儿童喘息、哮喘和过敏性鼻炎较为常见，可能具有产前起源。氧化应激与呼吸道疾病有关，但在产前阶段的氧化应激与儿童时期呼吸道和特应性疾病（尤其是婴儿期之后）的发展之间的关联尚不清楚。本研究旨在探讨产前氧化应激与儿童呼吸结局之间的关系，包括母亲种族的影响修饰。
我们前瞻性地研究了黑人和白人（n=717 和 363）母婴对子。我们在 2 期尿液中测量 F-异前列腺素（ng/mg-肌酐）。大约在 4 岁时，我们获得了父母报告的有医生诊断的哮喘（曾有）、当前喘息、当前哮喘（诊断、症状和/或药物治疗）和当前过敏性鼻炎（曾有定义为过去 12 个月）。我们使用多变量逻辑回归来估计每增加一个四分位距（IQR）的 F-异前列腺素浓度的调整后的优势比（aOR）和 95%置信区间（95%CI），同时控制混杂因素。我们使用交互项来检验母亲种族的修饰作用。
有医生诊断的哮喘和当前喘息、哮喘和过敏性鼻炎的患病率分别为 14%、19%、15%和 24%。F-异前列腺素的中位数（IQR）为 2.1（1.6，2.9）ng/mg-肌酐。产前 F-异前列腺素与有医生诊断的哮喘、当前喘息和当前哮喘之间的关联受到母亲种族的修饰。当前喘息的结果最强（aOR [95%CI]：白人 1.55 [1.16，2.06]；黑人 0.98 [0.78，1.22]；p 交互作用=0.01）。我们没有观察到 F-异前列腺素与过敏性鼻炎之间的关联。
产前尿液 F-异前列腺素可能是某些人群儿童喘息/哮喘的一个相关标志物。需要研究来了解潜在的机制和种族差异。
