Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Angew Chem Int Ed Engl. 2020 Apr 6;59(15):5890-5900. doi: 10.1002/anie.201911477. Epub 2020 Feb 4.
Two-dimensional (2D) nanomaterials are currently explored as novel photothermal agents because of their ultrathin structure, high specific surface area, and unique optoelectronic properties. In addition to single photothermal therapy (PTT), 2D nanomaterials have demonstrated significant potential in PTT-based synergistic therapies. In this Minireview, we summarize the recent progress in 2D nanomaterials for enhanced photothermal cancer therapy over the last five years. Their unique optical properties, typical synthesis methods, and surface modification are also covered. Emphasis is placed on their PTT and PTT-synergized chemotherapy, photodynamic therapy, and immunotherapy. The major challenges of 2D photothermal agents are addressed and the promising prospects are also presented.
二维（2D）纳米材料因其超薄结构、高比表面积和独特的光电特性而被探索作为新型光热剂。除了单一的光热治疗（PTT）之外，2D 纳米材料在基于 PTT 的协同治疗中显示出了巨大的潜力。在这篇综述中，我们总结了过去五年中 2D 纳米材料在增强光热癌症治疗方面的最新进展。还涵盖了它们独特的光学性质、典型的合成方法和表面修饰。重点介绍了它们在 PTT 和 PTT 协同化学治疗、光动力治疗和免疫治疗方面的应用。还讨论了 2D 光热剂面临的主要挑战，并提出了有前景的展望。
