Zhang Baomei, Wang Yang, Liu Jiyong, Zhai Guangxi
Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua Xilu, Jinan 250012, China.
Curr Med Chem. 2017;24(3):268-291. doi: 10.2174/0929867323666161019141817.
Graphene-based nanomaterials have drawn abundant interest in various fields such as biomedicine in recent years. Thanks to the ultra-high surface area of single-layered graphene, higher molecular loading is obtained. In addition, easy modifications were acquired because of its ample oxygen-content functional groups. Owing to its excellent physical- chemical properties, graphene-based nanomaterials have been widely explored as novel nanovectors for disease theranostics. In this article, we gave a comprehensive review of graphenebased nanomaterials, including introduction about different members of graphene family nanomaterials (GFNs), various modifications, toxicity and biomedical applications of graphene- based derivatives. More attentions were given to phototherapy in this paper. The mechanisms of photothermal and photodynamic therapy were also offered. Finally, the prospects and challenges of the graphene-based nanomaterials were discussed in this review.
近年来，基于石墨烯的纳米材料在生物医学等各个领域引起了广泛关注。由于单层石墨烯的超高表面积，可实现更高的分子负载量。此外，因其丰富的含氧官能团，易于进行修饰。基于石墨烯的纳米材料凭借其优异的物理化学性质，已被广泛探索作为疾病诊疗的新型纳米载体。在本文中，我们对基于石墨烯的纳米材料进行了全面综述，包括石墨烯家族纳米材料（GFNs）不同成员的介绍、各种修饰、基于石墨烯衍生物的毒性和生物医学应用。本文更多地关注了光疗。还介绍了光热疗法和光动力疗法的机制。最后，本综述讨论了基于石墨烯的纳米材料的前景和挑战。
