State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, Center for Aggregation-Induced Emission, South China University of Technology, Guangzhou, 510640, China.
Department of Medical Research, General Hospital of Southern Theater Command, PLA, Guangzhou, 510010, China.
Angew Chem Int Ed Engl. 2020 Jun 15;59(25):9952-9956. doi: 10.1002/anie.201916704. Epub 2020 Mar 11.
New, biocompatible materials with favorable antibacterial activity are highly desirable. In this work, we develop a unique conjugated polymer featuring aggregation-induced emission (AIE) for reliable bacterial eradication. Thanks to the AIE and donor-π-acceptor structure, this polymer shows a high reactive oxygen species (ROS)-generation ability compared to a low-mass model compound and the common photosensitizer Chlorin E6. Moreover, the selective binding of pathogenic microorganisms over mammalian cells was found, demonstrating its biocompatibility. The effective growth inhibition of bacteria upon polymer treatment under light irradiation was validated in vitro and in vivo. Notably, the recovery from infection after treatment with our polymer is faster than that with cefalotin. Thus, this polymer holds great promise in fighting against bacteria-related infections in practical applications.
新型的、具有良好抗菌活性的生物相容性材料是非常需要的。在这项工作中，我们开发了一种独特的具有聚集诱导发光（AIE）特性的共轭聚合物，用于可靠地杀菌。由于 AIE 和供体-π-受体结构，与低分子量模型化合物和常见的光敏剂 Chlorin E6 相比，该聚合物具有更高的活性氧（ROS）生成能力。此外，还发现该聚合物对致病微生物具有选择性结合，而对哺乳动物细胞具有生物相容性。在光照下聚合物处理后，细菌的有效生长抑制在体外和体内得到了验证。值得注意的是，与头孢菌素相比，用我们的聚合物治疗后的感染恢复速度更快。因此，这种聚合物在实际应用中对抗与细菌相关的感染具有很大的应用前景。
