State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, Center for Aggregation-Induced Emission, South China University of Technology, Guangzhou, 510640, China.
Shenzhen Institute of Aggregate Science and Technology, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, 518172, China.
ChemMedChem. 2021 Aug 5;16(15):2330-2338. doi: 10.1002/cmdc.202100138. Epub 2021 May 10.
Accurate diagnosis and treatment have been extensively developed in the field of biomedicine, which put forward higher requirements for the development of biomedical materials with high efficiency and selectivity. Among them, conjugated polymers featuring aggregation-induced emission (AIE) characteristics (AIE conjugated polymers) have stood out in recent years owing to their unique properties, such as intense solid emission, high light-harvesting ability, efficient energy transfer, and high O generation ability, which empower them with effective biomedical functions in fluorescence imaging (FLI), photodynamic therapy (PDT), FLI-guided PDT, two-photon excited photodynamic therapy (2PE-PDT), etc. In this review, we highlight recent progress in AIE conjugated polymers and their applications in anticancer and antibacterial areas based on FLI and PDT, and summarize the mechanism of color-tuned fluorescence emission and efficient O generation ability. The challenges and perspectives for the future development of AIE conjugated polymers are also discussed.
在生物医药领域，准确的诊断和治疗已经得到了广泛的发展，这对高效和选择性的生物医用材料的发展提出了更高的要求。其中，具有聚集诱导发光（AIE）特性的共轭聚合物（AIE 共轭聚合物）近年来脱颖而出，由于其独特的性质，如强烈的固体发光、高光捕获能力、高效能量转移和高 O 生成能力，使其在荧光成像（FLI）、光动力疗法（PDT）、FLI 引导的 PDT、双光子激发光动力疗法（2PE-PDT）等方面具有有效的生物医学功能。在本文中，我们重点介绍了 AIE 共轭聚合物的最新进展及其在基于 FLI 和 PDT 的抗癌和抗菌领域的应用，并总结了颜色可调荧光发射和高效 O 生成能力的机制。还讨论了 AIE 共轭聚合物未来发展的挑战和展望。
