Department of Clinical Sciences, Cardiology, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Princess Nourah Bint Abdulrahman University Cardiovascular Disease in Women Research Chair, Riyadh, Saudi Arabia.
J Diabetes Investig. 2020 Sep;11(5):1344-1351. doi: 10.1111/jdi.13226. Epub 2020 Mar 1.
AIMS/INTRODUCTION: Vitamin D levels are negatively correlated with prediabetes risk and hemoglobin A1c levels in individuals with prediabetes. The data are, however, scarce and inconsistent among different populations. We aimed to assess the association of vitamin D with prediabetes risk and hemoglobin A1c levels in young Saudi women with normoglycemia and prediabetes.
We analyzed the data of individuals without diabetes (without diabetes history and hemoglobin A1c <6.4%) from the Princess Nourah bint Abdulrahman University's non-communicable diseases student registry. Demographic data, anthropometric and blood pressure measurements, and hemoglobin A1c and vitamin D results were retrieved and analyzed.
In total, 345 participants were included in the analysis. The prediabetes status showed no association with vitamin D levels, but it was significantly associated with the participants' weight and body mass index. Additionally, there was no correlation between the levels of vitamin D and hemoglobin A1c across the whole population, even after correction for body mass index. However, in the body mass index subgroups, when individuals with potentially harmful levels of vitamin D (>125 nmol/L) were excluded, a positive association was detected between vitamin D and hemoglobin A1c levels in the underweight individuals. Hemoglobin A1c values showed a positive correlation only with bodyweight and body mass index.
Vitamin D levels did not predict prediabetes status and showed no correlation with hemoglobin A1c levels in this population. Vitamin D levels' effect on the risk of prediabetes might be small compared with other well-established risk factors, such as obesity.
目的/引言：维生素 D 水平与糖尿病前期个体的糖尿病前期风险和糖化血红蛋白 A1c 水平呈负相关。然而，不同人群的数据仍然很少且不一致。我们旨在评估在血糖正常和患有糖尿病前期的年轻沙特女性中，维生素 D 与糖尿病前期风险和糖化血红蛋白 A1c 水平之间的关联。
我们分析了 Princess Nourah bint Abdulrahman 大学非传染性疾病学生登记处无糖尿病（无糖尿病史和糖化血红蛋白 A1c<6.4%）个体的数据。检索并分析了人口统计学数据、人体测量和血压测量以及糖化血红蛋白 A1c 和维生素 D 结果。
总共纳入了 345 名参与者进行分析。糖尿病前期状态与维生素 D 水平无关，但与参与者的体重和体重指数显著相关。此外，即使在校正体重指数后，整个人群的维生素 D 水平与糖化血红蛋白 A1c 之间也没有相关性。然而，在体重指数亚组中，当排除维生素 D 水平可能有害（>125 nmol/L）的个体时，在体重不足的个体中，维生素 D 与糖化血红蛋白 A1c 水平之间存在正相关。糖化血红蛋白 A1c 值仅与体重和体重指数呈正相关。
在该人群中，维生素 D 水平不能预测糖尿病前期状态，与糖化血红蛋白 A1c 水平也没有相关性。与肥胖等其他已确立的危险因素相比，维生素 D 水平对糖尿病前期风险的影响可能较小。
