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CT 注射器技术和对比剂粘度对血管增强的影响：在循环模型中的评估。

Impact of CT Injector Technology and Contrast Media Viscosity on Vascular Enhancement: Evaluation in a Circulation Phantom.

机构信息

Bayer U.S. LLC, Bayer Pharmaceuticals, Radiology R&D, Indianola, PA 15051, USA.

Bayer AG, MR & CT Contrast Media Research, Berlin, Germany.

出版信息

Br J Radiol. 2020 May 1;93(1109):20190868. doi: 10.1259/bjr.20190868. Epub 2020 Feb 20.

DOI:10.1259/bjr.20190868
PMID:32017607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7217576/
Abstract

OBJECTIVE

To assess the impact of piston-based peristaltic injection system technology and contrast media viscosity on achievable iodine delivery rates (IDRs) and vascular enhancement in a pre-clinical study.

METHODS

Four injectors were tested: MEDRAD Centargo, MEDRAD Stellant, CT Exprès, and CT motion using five contrast media [iopromide (300 and 370 mgI ml), iodixanol 320 mgI ml, iohexol 350 mgI ml, iomeprol 400 mgI ml]. Three experiments were performed evaluating achievable IDR and corresponding enhancement in a circulation phantom.

RESULTS

Experiment I: Centargo provided the highest achievable IDRs with all tested contrast media ( < 0.05). Iopromide 370 yielded the highest IDR with an 18G catheter (3.15 gI/s); iopromide 300 yielded the highest IDR with 20G (2.70 gI/s) and 22G (1.65 gI/s) catheters ( < 0.05).Experiment II: with higher achievable IDRs, piston-based injectors provided significantly higher peak vascular enhancement (up to 48% increase) than the peristaltic injectors with programmed IDRs from 1.8 to 2.4 gI/s ( < 0.05).Experiment III: with programmed IDRs ( 1.5 gI/s) achievable by all injection systems, Centargo, with sharper measured bolus shape, provided significant increases in enhancement of 34-73 HU in the pulmonary artery with iopromide 370 ( < 0.05).

CONCLUSION

The tested piston-based injection systems combined with low viscosity contrast media provide higher achievable IDRs and higher peak vascular enhancement than the tested peristaltic-based injectors. With equivalent IDRs, Centargo provides higher peak vascular enhancement due to improved bolus shape.

ADVANCES IN KNOWLEDGE

This paper introduces a new parameter to compare expected performance among contrast media: the concentration/viscosity ratio. Additionally, it demonstrates previously unexplored impacts of bolus shape on vascular enhancement.

摘要

目的

在临床前研究中，评估基于活塞的蠕动注射系统技术和对比剂粘度对可实现碘输送率（IDR）和血管增强的影响。

方法

测试了四种注射器：MEDRAD Centargo、MEDRAD Stellant、CT Exprès 和 CT motion，使用了五种对比剂[碘普罗胺（300 和 370mgI/ml）、碘昔醇 320mgI/ml、碘海醇 350mgI/ml、碘美普尔 400mgI/ml]。进行了三项实验，评估循环模型中可实现的 IDR 和相应的增强。

结果

实验 I：Centargo 提供了所有测试对比剂的最高可实现 IDR（<0.05）。18G 导管的碘普罗胺 370 产生了最高的 IDR（3.15gI/s）；20G（2.70gI/s）和 22G（1.65gI/s）导管的碘普罗胺 300 产生了最高的 IDR（<0.05）。实验 II：活塞式注射器具有更高的可实现 IDR，与具有 1.8 至 2.4gI/s 编程 IDR 的蠕动式注射器相比，可提供显著更高的峰值血管增强（最高增加 48%）（<0.05）。实验 III：在所有注射系统都可实现编程 IDR（1.5gI/s）的情况下，Centargo 提供了使用碘普罗胺 370 时肺动脉增强 34-73HU 的显著增加（<0.05），其测量的射流形状更陡峭。

结论

与测试的基于蠕动的注射器相比，所测试的基于活塞的注射系统结合低粘度对比剂可提供更高的可实现 IDR 和更高的峰值血管增强。在等效 IDR 的情况下，Centargo 由于改进的射流形状提供了更高的峰值血管增强。

知识进步

本文引入了一个新参数来比较不同对比剂的预期性能：浓度/粘度比。此外，它还证明了射流形状对血管增强的以前未探索的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd0/7217576/27beab154436/bjr.20190868.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd0/7217576/cce21745a8a6/bjr.20190868.g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd0/7217576/9e1b94c2eb03/bjr.20190868.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd0/7217576/6e6d04e863e1/bjr.20190868.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd0/7217576/fb1f945ed7da/bjr.20190868.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd0/7217576/04efaf3e7bbf/bjr.20190868.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd0/7217576/27beab154436/bjr.20190868.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd0/7217576/cce21745a8a6/bjr.20190868.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd0/7217576/d4ce3a2ad945/bjr.20190868.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd0/7217576/9e1b94c2eb03/bjr.20190868.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd0/7217576/6e6d04e863e1/bjr.20190868.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd0/7217576/fb1f945ed7da/bjr.20190868.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd0/7217576/04efaf3e7bbf/bjr.20190868.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd0/7217576/27beab154436/bjr.20190868.g007.jpg

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