Caruso Damiano, Eid Marwen, Schoepf U Joseph, De Santis Domenico, Varga-Szemes Akos, Mangold Stefanie, Canstein Christian, Lesslie Virginia W, Fuller Stephen R, Ball B Devon, Laghi Andrea, De Cecco Carlo N
From the *Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC; †Department of Radiological Sciences, Oncology and Pathology, University of Rome "Sapienza," Rome, Italy; ‡Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC; §Department of Diagnostic and Interventional Radiology, Eberhard-Karls University Tübingen, Tübingen, Germany; and ∥Siemens Medical Solutions, Malvern, PA.
J Comput Assist Tomogr. 2017 Sep/Oct;41(5):804-810. doi: 10.1097/RCT.0000000000000613.
The aim of this study was to investigate the minimum iodine delivery rate (IDR) and contrast media (CM) volume required for diagnostic contrast enhancement of 350 HU (Hounsfield units) in the ascending aorta at different kV settings.
Dynamic computed tomography acquisitions from 70 to 150 kV were performed in a circulation phantom. First, injections with IDR ranging from 0.1 to 2.0 g I/s were tested for each kV. In the second part, the IDR was held constant, whereas the CM volume was reduced from 50 to 10 mL. Diagnostic aortic peak enhancement for each kV was compared using the Kruskal-Wallis test. P < 0.05 was considered statistically significant.
The mean aortic peak enhancement for all diagnostic IDRs was 368.7 ± 11.1 HU. Diagnostic IDRs returned similar aortic peak enhancement values for all protocols (all P ≥ 0.18). For the second part of the study, a diagnostic enhancement was yielded by using a minimum of 30 mL of CM for 110 kV, 25 mL for 100 and 90 kV, and 15 mL for 80 and 70 kV.
Our study suggests that a differentiated approach reducing the CM volume for tube voltages of less than 120 kV and increasing the IDR for higher kV settings seems to be the most effective approach.
本研究旨在探讨在不同千伏设置下，升主动脉诊断性对比增强达到350亨氏单位（HU）所需的最低碘输送率（IDR）和对比剂（CM）体积。
在循环体模中进行70至150 kV的动态计算机断层扫描采集。首先，对每个千伏测试IDR范围为0.1至2.0 g I/s的注射。在第二部分中，IDR保持恒定，而CM体积从50 mL减少到10 mL。使用Kruskal-Wallis检验比较每个千伏的诊断性主动脉峰值增强。P < 0.05被认为具有统计学意义。
所有诊断性IDR的平均主动脉峰值增强为368.7±11.1 HU。所有方案的诊断性IDR返回相似的主动脉峰值增强值（所有P≥0.18）。对于研究的第二部分，110 kV至少使用30 mL CM、100和90 kV使用25 mL、80和70 kV使用15 mL可产生诊断性增强。
我们的研究表明，对于低于120 kV的管电压降低CM体积，对于更高的千伏设置增加IDR的差异化方法似乎是最有效的方法。
