Neurosciences Department, Psychiatry Discipline, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Biochemistry and Pharmacology Department, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
PLoS One. 2020 Feb 4;15(2):e0228648. doi: 10.1371/journal.pone.0228648. eCollection 2020.
Antipsychotic medication, stress, gender, and age are factors that influence prolactin levels in patients with psychosis. The aim of the study was to investigate the level of prolactin response to antipsychotic treatment in acute patients, taking into account the total duration of psychosis.
The study was conducted on 170 acute patients with schizophrenia spectrum disorders and bipolar disorder. Subjects were divided into three subgroups according to the duration of the psychosis (less than 5 years, between 5 and 10 years and more than 10 years of disorder duration). The initial prolactin response under antipsychotic treatment was measured, while the severity of the psychiatric symptoms was assessed with the BPRS (Brief Psychiatric Rating Scale). Hyperprolactinemia was found in 120 (70.6%) patients, amongst which 80 (66.7%) were females and 40 (33.3%) were males. The average increase in prolactinemia was 2.46 times the maximum value in women, and 1.59 times in men. Gender (β = 0.27, p<0.0001), type of antipsychotic medication according to potency of inducing hyperprolactinemia (β = -0.23, p<0.003), and the duration of psychosis over 10 years (β = -0.15, p = 0.04) significantly predicted prolactin levels, when age, diagnosis, antipsychotic category (conventional/atypical/combinations of antipsychotics), and BPRS total scores were controlled for.
Prolactin levels in patients treated with antipsychotic medication appeared to depend on patients' gender, on the type of antipsychotic medication according to potency of inducing hyperprolactinemia, and on the duration of the psychosis. An increase in prolactin levels was associated with female gender, while the use of prolactin sparing antipsychotics and a duration of psychosis over 10 years were associated with lower prolactin levels.
抗精神病药物、压力、性别和年龄是影响精神病患者催乳素水平的因素。本研究的目的是调查抗精神病治疗对急性患者催乳素反应的水平，同时考虑到精神病的总病程。
本研究纳入了 170 名精神分裂症谱系障碍和双相情感障碍的急性患者。根据精神病的持续时间（<5 年、5-10 年和>10 年）将患者分为三个亚组。在抗精神病治疗下测量初始催乳素反应，同时使用 BPRS（简明精神病评定量表）评估精神症状的严重程度。120 名（70.6%）患者出现高催乳素血症，其中 80 名（66.7%）为女性，40 名（33.3%）为男性。女性催乳素血症的平均增长率为最大正常值的 2.46 倍，男性为 1.59 倍。性别（β=0.27，p<0.0001）、根据催乳素升高的能力分类的抗精神病药物类型（β=-0.23，p<0.003）以及病程超过 10 年（β=-0.15，p=0.04）在控制年龄、诊断、抗精神病药物类别（传统/非典型/抗精神病药物联合治疗）和 BPRS 总分后显著预测催乳素水平。
接受抗精神病药物治疗的患者的催乳素水平似乎取决于患者的性别、根据催乳素升高能力分类的抗精神病药物类型以及精神病的病程。催乳素水平的升高与女性性别有关，而使用催乳素节省型抗精神病药物和病程超过 10 年与较低的催乳素水平有关。
