Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Wuya College of Innovation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Fitoterapia. 2020 Apr;142:104490. doi: 10.1016/j.fitote.2020.104490. Epub 2020 Feb 1.
Privileged structures are widely used in the process of drug design, and provide an effective template in medicinal chemistry. Diarylheptanoids are a class of structurally distinctive compounds with a wide variety of bioactivity, raising keenly interest in the past decades. Turmeric is a golden spice from the rhizome of the plant Curcuma longa, used for food preparations and giving color since ancient times. Curcumin, obtained from turmeric, has showed widely biological abilities with low toxicity in recent studied. Thus, a spice originally common in the kitchen has recently broadened its application to the clinic. This review aims to highlight diarylheptanoid as a privileged scaffold in drug discovery. In this review, we summarized diverse biological and pharmacological effects of diarylheptanoids and explored the therapeutic application and development of diet based on their structure.
优势结构在药物设计过程中被广泛应用，并为药物化学提供了有效的模板。二芳基庚烷类化合物是一类结构独特的化合物，具有广泛的生物活性，在过去几十年中引起了极大的兴趣。姜黄是一种来自植物姜黄根茎的金色香料，自古以来就用于食品制备和着色。从姜黄中提取的姜黄素在最近的研究中表现出广泛的生物活性和低毒性。因此，一种原本在厨房中常见的香料最近已经将其应用扩展到了临床。本综述旨在强调二芳基庚烷类化合物作为药物发现中的优势骨架。在本综述中，我们总结了二芳基庚烷类化合物的多种生物学和药理学作用，并根据其结构探讨了基于饮食的治疗应用和开发。
