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高岭土-麦芽糊精递送系统的设计与评估：抗氧化、抗菌及细胞毒性活性评估

Design and Evaluation of a -Kaolinite-Maltodextrin Delivery System: Antioxidant, Antimicrobial, and Cytotoxic Activity Assessment.

作者信息

Segneanu Adina-Elena, Bradu Ionela Amalia, Vlase Gabriela, Vlase Titus, Bejenaru Cornelia, Bejenaru Ludovic Everard, Mogoşanu George Dan, Ciocîlteu Maria Viorica, Herea Dumitru-Daniel, Boia Eugen Radu

机构信息

Department of Chemistry, Institute for Advanced Environmental Research, West University of Timişoara (ICAM-WUT), 4 Oituz Street, 300086 Timişoara, Romania.

Research Center for Thermal Analyzes in Environmental Problems, West University of Timişoara, 16 Johann Heinrich Pestalozzi Street, 300115 Timişoara, Romania.

出版信息

Pharmaceutics. 2025 Jun 6;17(6):751. doi: 10.3390/pharmaceutics17060751.

DOI:10.3390/pharmaceutics17060751
PMID:40574063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12196066/
Abstract

: Roscoe () is widely recognized for its diverse biological activities; however, the stability and bioavailability of its bioactive compounds remain significant challenges. This study aimed to investigate an innovative approach to enhance the stability and efficacy of phytoconstituents through advanced encapsulation techniques. : Two novel carrier systems were developed: () direct micro-spray encapsulation of in maltodextrin (MZO) and () a two-step process involving the creation of a kaolinite-based phytocarrier system (ZO-kaolinite), followed by micro-spray encapsulation in maltodextrin to form the MZO-kaolinite system. : Comprehensive chemical profiling using GC-MS and ESI-QTOF-MS identified 105 phytochemicals, including terpenoids, gingerols, shogaols, flavonoids, and phenolic acids. Morphostructural analyses (XRD, FTIR, Raman, SEM) confirmed the successful development of the newly engineered kaolinite carrier systems (ZO-kaolinite and MZO-kaolinite systems). Both the ZO-kaolinite and MZO-kaolinite systems exhibited superior antioxidant activity, potent antimicrobial efficacy against major bacterial pathogens (, , , , , ), and enhanced cytotoxicity against MCF-7, HCT-116, and HeLa cancer cell lines. : This study underscores the synergistic action of kaolinite and maltodextrin in developing multifunctional therapeutic systems, emphasizing the importance of phytoconstituent stabilization and nanotechnology in addressing antimicrobial resistance and advancing innovative medical applications.

摘要

罗斯科（Roscoe）因其多样的生物活性而广受认可；然而，其生物活性化合物的稳定性和生物利用度仍然是重大挑战。本研究旨在探究一种创新方法，通过先进的包封技术提高植物成分的稳定性和功效。开发了两种新型载体系统：（1）将罗斯科直接微喷雾包封在麦芽糊精中（MZO），以及（2）两步法，先创建基于高岭土的植物载体系统（ZO-高岭土），然后微喷雾包封在麦芽糊精中形成MZO-高岭土系统。使用气相色谱-质谱联用仪（GC-MS）和电喷雾电离-四极杆飞行时间质谱仪（ESI-QTOF-MS）进行的综合化学分析鉴定出105种植物化学物质，包括萜类化合物、姜辣素、姜烯酚、黄酮类化合物和酚酸。形态结构分析（X射线衍射、傅里叶变换红外光谱、拉曼光谱、扫描电子显微镜）证实了新设计的高岭土载体系统（ZO-高岭土和MZO-高岭土系统）的成功开发。ZO-高岭土和MZO-高岭土系统均表现出卓越的抗氧化活性、对主要细菌病原体（大肠杆菌、金黄色葡萄球菌、肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌、白色念珠菌）的强效抗菌功效，以及对MCF-7、HCT-116和HeLa癌细胞系增强的细胞毒性。本研究强调了高岭土和麦芽糊精在开发多功能治疗系统中的协同作用，突出了植物成分稳定化和纳米技术在应对抗菌耐药性及推进创新医学应用方面的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/6eb0a85eb35d/pharmaceutics-17-00751-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/03a5c50f1295/pharmaceutics-17-00751-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/01c81dbb4af8/pharmaceutics-17-00751-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/bba65e374e2f/pharmaceutics-17-00751-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/ae8fe0964851/pharmaceutics-17-00751-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/3a838e095260/pharmaceutics-17-00751-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/7deedf15a38d/pharmaceutics-17-00751-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/ea53d1ba6ab3/pharmaceutics-17-00751-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/7626aad52c6c/pharmaceutics-17-00751-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/a2ba728a00c1/pharmaceutics-17-00751-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/ae4dd8a818e3/pharmaceutics-17-00751-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/d3afd0e94c6e/pharmaceutics-17-00751-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/c23b2761ebdf/pharmaceutics-17-00751-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/6feefc9a2b20/pharmaceutics-17-00751-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/6eb0a85eb35d/pharmaceutics-17-00751-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/03a5c50f1295/pharmaceutics-17-00751-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/01c81dbb4af8/pharmaceutics-17-00751-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/bba65e374e2f/pharmaceutics-17-00751-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/ae8fe0964851/pharmaceutics-17-00751-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/3a838e095260/pharmaceutics-17-00751-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/7deedf15a38d/pharmaceutics-17-00751-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/ea53d1ba6ab3/pharmaceutics-17-00751-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/7626aad52c6c/pharmaceutics-17-00751-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/a2ba728a00c1/pharmaceutics-17-00751-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/ae4dd8a818e3/pharmaceutics-17-00751-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/d3afd0e94c6e/pharmaceutics-17-00751-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/c23b2761ebdf/pharmaceutics-17-00751-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/6feefc9a2b20/pharmaceutics-17-00751-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5529/12196066/6eb0a85eb35d/pharmaceutics-17-00751-g014.jpg

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[3]
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[7]
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