Molecular Toxicology Group, Department of Biology, University of Konstanz, 78457, Konstanz, Germany.
Toxicol Lett. 2020 May 15;324:95-103. doi: 10.1016/j.toxlet.2020.01.024. Epub 2020 Feb 1.
Sulfur mustard (SM) is a toxicant and chemical warfare agent with strong vesicant properties. The mechanisms behind SM-induced toxicity are not fully understood and no antidote or effective therapy against SM exists. Both, the risk of SM release in asymmetric conflicts or terrorist attacks and the usage of SM-derived nitrogen mustards as cancer chemotherapeutics, render the mechanisms of mustard-induced toxicity a highly relevant research subject. Herein, we review a central role of the abundant cellular molecule nicotinamide adenine dinucleotide (NAD) in molecular mechanisms underlying SM toxicity. We also discuss the potential beneficial effects of NAD precursors in counteracting SM-induced damage.
硫芥（SM）是一种具有强烈腐蚀性的有毒物质和化学战剂。SM 诱导毒性的机制尚未完全阐明，也没有针对 SM 的解毒剂或有效治疗方法。无论是在非对称冲突或恐怖袭击中 SM 释放的风险，还是作为癌症化疗药物的 SM 衍生氮芥的使用，都使得 mustard 诱导毒性的机制成为一个高度相关的研究课题。在这里，我们回顾了丰富的细胞分子烟酰胺腺嘌呤二核苷酸（NAD）在 SM 毒性的分子机制中的核心作用。我们还讨论了 NAD 前体在对抗 SM 诱导损伤方面的潜在有益作用。
