Ren Zhongxiang, Xu Yetong, Li Tiejun, Sun Weizhong, Tang Zhiru, Wang Yongsheng, Zhou Kaifeng, Li Jigang, Ding Qi, Liang Kaiyang, Wu Liuting, Yin Yulong, Sun Zhihong
Laboratory for Bio-feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China.
Anim Nutr. 2022 Jun 22;10:360-371. doi: 10.1016/j.aninu.2022.06.009. eCollection 2022 Sep.
Nicotinamide adenine dinucleotide (NAD) is an enzyme cofactor, co-substrate, and redox factor in all living cells and is necessary for maintaining cell metabolism. It has been shown that appropriate supplementation of NAD precursors or inhibition of NAD-depleting enzymes can promote mitochondrial oxidative phosphorylation and improve host energy utilization efficiency. In addition, increasing evidence indicates that the gut microbiota plays a pivotal role in host metabolism. Theoretically, there should be a close correlation among NAD, gut microbiota, and host metabolism; however, the information is limited. In this review, we summarize the metabolic process of NAD and its impact on host metabolism, the link between gut microbiota and host metabolism, as well as the potential effects of NAD on microbial metabolism, providing a new perspective on the interaction between gut microbiota and host metabolism.
烟酰胺腺嘌呤二核苷酸（NAD）是所有活细胞中的一种酶辅因子、共底物和氧化还原因子，对维持细胞代谢至关重要。研究表明，适当补充NAD前体或抑制消耗NAD的酶可促进线粒体氧化磷酸化并提高宿主能量利用效率。此外，越来越多的证据表明肠道微生物群在宿主代谢中起关键作用。理论上，NAD、肠道微生物群和宿主代谢之间应该存在密切关联；然而，相关信息有限。在这篇综述中，我们总结了NAD的代谢过程及其对宿主代谢的影响、肠道微生物群与宿主代谢之间的联系，以及NAD对微生物代谢的潜在影响，为肠道微生物群与宿主代谢之间的相互作用提供了新的视角。
