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全国性美国研究中的血清叶酸代谢物、哮喘和肺功能。

Serum folate metabolites, asthma, and lung function in a nationwide US study.

机构信息

Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pa.

Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pa.

出版信息

J Allergy Clin Immunol. 2020 Jul;146(1):220-222.e8. doi: 10.1016/j.jaci.2020.01.034. Epub 2020 Feb 1.

DOI:10.1016/j.jaci.2020.01.034
PMID:32018028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7343583/
Abstract

In a U.S. nationwide study, a high serum 5-MTHF to UMFA ratio is associated with decreased odds of asthma, increased FEV in children and adults, and increased FVC in adults.

摘要

在美国全国性研究中，血清 5-MTHF 与 UMFA 比值较高与哮喘发病几率降低、儿童和成人的 FEV 增加以及成人的 FVC 增加相关。

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本文引用的文献

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Association Between Folate Metabolites and the Development of Food Allergy in Children.叶酸代谢产物与儿童食物过敏发生之间的关联
J Allergy Clin Immunol Pract. 2020 Jan;8(1):132-140.e5. doi: 10.1016/j.jaip.2019.06.017. Epub 2019 Jun 25.
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Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children.血清叶酸浓度、哮喘、特应性与秘鲁儿童哮喘控制。
Respir Med. 2017 Dec;133:29-35. doi: 10.1016/j.rmed.2017.10.026. Epub 2017 Nov 3.
3
A Daily Dose of 5 mg Folic Acid for 90 Days Is Associated with Increased Serum Unmetabolized Folic Acid and Reduced Natural Killer Cell Cytotoxicity in Healthy Brazilian Adults.在健康的巴西成年人中，连续90天每日服用5毫克叶酸与血清中未代谢叶酸增加及自然杀伤细胞细胞毒性降低有关。
J Nutr. 2017 Sep;147(9):1677-1685. doi: 10.3945/jn.117.247445. Epub 2017 Jul 19.
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Folate and asthma.叶酸与哮喘。
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Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations.用于 3-95 岁年龄范围的肺量测定的多民族参考值：全球肺功能 2012 方程。
Eur Respir J. 2012 Dec;40(6):1324-43. doi: 10.1183/09031936.00080312. Epub 2012 Jun 27.
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Atopy, asthma, and lung function in relation to folate and vitamin B(12) in adults.特应性、哮喘与成人叶酸和维生素 B12 及肺功能的关系。
Allergy. 2010 Nov;65(11):1446-54. doi: 10.1111/j.1398-9995.2010.02378.x.
7
The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake.人肝脏中二氢叶酸还原酶极其缓慢且多变的活性及其对高叶酸摄入量的影响。
Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15424-9. doi: 10.1073/pnas.0902072106. Epub 2009 Aug 24.
8
Higher serum folate levels are associated with a lower risk of atopy and wheeze.较高的血清叶酸水平与较低的特应性和喘息风险相关。
J Allergy Clin Immunol. 2009 Jun;123(6):1253-9.e2. doi: 10.1016/j.jaci.2009.03.007. Epub 2009 May 5.
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