Matsui Elizabeth C, Matsui William
Division of Pediatric Allergy and Immunology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
J Allergy Clin Immunol. 2009 Jun;123(6):1253-9.e2. doi: 10.1016/j.jaci.2009.03.007. Epub 2009 May 5.
Folic acid is known to be associated with inflammatory diseases, but the relationship between folic acid and allergic diseases is unclear.
The purpose of the study was to examine the relationship between serum folate levels and markers of atopy, wheeze, and asthma.
Data were obtained from the 2005-2006 National Health and Nutrition Examination Survey in which serum folate and total IgE levels were measured in 8083 subjects 2 years of age and older. A high total IgE level was defined as greater than 100 kU/L. Allergen-specific IgE levels were measured for a panel of 5 common aeroallergens. Atopy was defined as at least 1 positive allergen-specific IgE level. Doctor-diagnosed asthma and wheeze in the previous 12 months were assessed by means of questionnaire.
Serum folate levels were inversely associated with total IgE levels (P < .001). The odds of a high total IgE level, atopy, and wheeze decreased across quintiles of serum folate levels, indicating a dose-response relationship between serum folate levels and these outcomes. Each of these associations remained statistically significant after adjusting for age, sex, race/ethnicity, and poverty index ratio. Adjusted odds ratios associated with the fifth quintile of folate relative to the first quintile were as follows: high IgE level, 0.70 (95% CI, 0.53-0.92); atopy, 0.69 (95% CI, 0.57-0.85); and wheeze, 0.60 (95% CI, 0.44-0.82). Higher folate levels were also associated with a lower risk of doctor-diagnosed asthma, but this finding was not statistically significant (odds ratio for fifth quintile vs first quintile, 0.84 [95% CI, 0.70-1.02]).
Serum folate levels are inversely associated with high total IgE levels, atopy, and wheeze.
已知叶酸与炎症性疾病有关，但叶酸与过敏性疾病之间的关系尚不清楚。
本研究旨在探讨血清叶酸水平与特应性、喘息和哮喘标志物之间的关系。
数据来自2005 - 2006年国家健康和营养检查调查，其中对8083名2岁及以上受试者测量了血清叶酸和总IgE水平。总IgE水平高定义为大于100 kU/L。对一组5种常见气传变应原测量了变应原特异性IgE水平。特应性定义为至少1种变应原特异性IgE水平呈阳性。通过问卷调查评估过去12个月内医生诊断的哮喘和喘息情况。
血清叶酸水平与总IgE水平呈负相关（P <.001）。总IgE水平高、特应性和喘息的几率随着血清叶酸水平五分位数的升高而降低，表明血清叶酸水平与这些结果之间存在剂量反应关系。在调整年龄、性别、种族/民族和贫困指数比后，这些关联中的每一个仍具有统计学意义。相对于第一五分位数，与叶酸第五五分位数相关的调整后比值比如下：高IgE水平，0.70（95% CI，0.53 - 0.92）；特应性，0.69（95% CI，0.57 - 0.85）；喘息，0.60（95% CI，0.44 - 0.82）。较高的叶酸水平也与医生诊断哮喘的较低风险相关，但这一发现无统计学意义（第五五分位数与第一五分位数的比值比，0.84 [95% CI，0.70 - 1.02]）。
血清叶酸水平与高总IgE水平、特应性和喘息呈负相关。
