Department of Public Health Sciences, Karolinska Institutet, Sweden; Department of Medical and Surgical Specialties Radiological Sciences and Public Health, Unit of Hygiene, Epidemiology, and Public Health, University of Brescia, Italy; ATS Brescia (Brescia Health Protection Agency), Brescia, Italy.
Department of Medical and Surgical Specialties Radiological Sciences and Public Health, Unit of Hygiene, Epidemiology, and Public Health, University of Brescia, Italy.
Sci Total Environ. 2020 Apr 20;714:136660. doi: 10.1016/j.scitotenv.2020.136660. Epub 2020 Jan 11.
This study aimed to assess the longitudinal association between PCB exposure and the subsequent occurrence of hypertension in a highly polluted area. The study subjects had at least one PCB serum measurement between 2003 and 2014 and were followed up to the end of 2017. Hypertension cases were obtained from the Brescia Health Protection Agency database. Risk ratios of hypertension for total PCBs, high-, middle- and low-chlorinated groups and some common congeners were estimated using Poisson regression models. 1031 subjects were included (43.4% males, mean age 45.3 years). 229 subjects developed hypertension during the follow-up. Total PCBs, middle- and high-chlorinated PCBs, and particularly PCB congeners 138, 153 and 180 were associated with an about 2-fold increased risk of hypertension comparing the third with first tertile of distribution. After lipid-standardization of PCB serum values, the excess risk showed only a slight attenuation. A dose-response linear relationship of the risk of hypertension by PCB serum concentrations as continuous variables was also observed. The PCBs-hypertension association was stronger in overweight/obese subjects than those with normal body mass index. In this prospective cohort study the serum levels of total and middle to high chlorinated (≥6 Cl) PCBs were associated with an increased risk of hypertension, particularly among overweight/obese subjects.
本研究旨在评估高度污染地区个体体内多氯联苯（PCB）暴露与随后高血压发生之间的纵向关联。研究对象在 2003 年至 2014 年期间至少进行过一次 PCB 血清测量，并随访至 2017 年底。高血压病例从布雷西亚卫生保护局数据库中获得。使用泊松回归模型估计总 PCB、高氯、中氯和低氯组以及一些常见同系物与高血压的风险比。共纳入 1031 名研究对象（男性占 43.4%，平均年龄 45.3 岁）。在随访期间，229 名研究对象发生了高血压。与分布的第一三分位相比，总 PCB、中氯和高氯 PCB 以及特定的 PCB 同系物 138、153 和 180 与高血压风险增加约 2 倍相关。对 PCB 血清值进行脂质标准化后，超额风险仅略有减弱。还观察到高血压风险与 PCB 血清浓度作为连续变量之间呈线性剂量反应关系。在超重/肥胖个体中，PCBs 与高血压之间的关联比在 BMI 正常的个体中更强。在这项前瞻性队列研究中，总 PCB 和中至高氯（≥6 Cl）PCB 的血清水平与高血压风险增加相关，尤其是在超重/肥胖个体中。
