羟基脲抑制脱氧核糖核酸合成过程中λ原噬菌体的紫外线诱导
Ultraviolet induction of prophage lambda during inhibition of deoxyribonucleic acid synthesis by hydroxyurea.
作者信息
Lydersen B K, Pollard E C
出版信息
J Bacteriol. 1977 Feb;129(2):698-701. doi: 10.1128/jb.129.2.698-701.1977.
Abstract
Hydroxyurea inhibited synthesis of certain deoxyribonucleic acid (DNA) precursors and causes the cessation of DNA synthesis. It did not cause induction of lambda. Superinfection of an irradiated lysogen with lambdaind- could prevent induction, but the percentage of cells protected decreased as the time between irradiation and superinfection increased. The presence of hydroxyurea did not increase the time during which cells could be rescued by superinfection. The accumulation of DNA precursors after ultraviolet or ionizing radiation was not necessary for the induction of lambda prophage to occur.
摘要
羟基脲抑制某些脱氧核糖核酸（DNA）前体的合成并导致DNA合成停止。它不会引起λ噬菌体的诱导。用λind-对受辐照的溶原菌进行超感染可以阻止诱导，但随着辐照和超感染之间时间的增加，受保护细胞的百分比会降低。羟基脲的存在并没有增加细胞可以通过超感染获救的时间。紫外线或电离辐射后DNA前体的积累对于λ原噬菌体的诱导发生不是必需的。
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