Allahham Nour, Fina Fabrizio, Marcuta Carmen, Kraschew Lilia, Mohr Wolfgang, Gaisford Simon, Basit Abdul W, Goyanes Alvaro
FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK.
Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Pharmaceutics. 2020 Jan 30;12(2):110. doi: 10.3390/pharmaceutics12020110.
The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug-cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of mannitol were prepared and tested, and a commercial ondansetron orally disintegrating tablet (ODT) product (Vonau Flash) was also investigated for comparison. Both 3D printed formulations disintegrated at ~15 s and released more than 90% of the drug within 5 min independent of the mannitol content; these results were comparable to those obtained with the commercial product. This work demonstrates the potential of SLS 3DP to fabricate orodispersible printlets with characteristics similar to a commercial ODT, but with the added benefit of using a manufacturing technology able to prepare medicines individualized to the patient.
这项工作的目的是探索使用选择性激光烧结（SLS）3D打印（3DP）来制造含昂丹司琼的口腔崩解微片（ODP）的可行性。首先将昂丹司琼制成药物 - 环糊精复合物，然后与填充剂甘露醇混合。制备并测试了两种甘露醇含量不同的3D打印制剂，还对一种市售的昂丹司琼口腔崩解片（ODT）产品（Vonau Flash）进行了研究以作比较。两种3D打印制剂均在约15秒内崩解，且在5分钟内释放了超过90%的药物，与甘露醇含量无关；这些结果与市售产品相当。这项工作证明了SLS 3DP制造具有与市售ODT相似特性的口腔崩解微片的潜力，而且还有使用能够制备针对患者个体化药物的制造技术这一额外优势。
